Sorcs3 MGI Mouse Gene Detail - MGI:1913923 - sortilin-related VPS10 domain containing receptor 3

Symbol

Sorcs3
Name

sortilin-related VPS10 domain containing receptor 3
Synonyms

6330404A12Rik

Feature Type

protein coding gene
IDs

MGI:1913923
NCBI Gene: 66673
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr19:48194464-48793944 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 41.32 cM
Mapping Data

2 experiments

SNPs within 2kb

17367 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913923	protein coding gene	Chr19:48194464-48793944 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025238	protein coding gene	Chr19:48097992-48735046 (+)
A/J	MGP_AJ_G0025214	protein coding gene	Chr19:45676169-46280063 (+)
AKR/J	MGP_AKRJ_G0025183	protein coding gene	Chr19:47157026-47768257 (+)
BALB/cJ	MGP_BALBcJ_G0025209	protein coding gene	Chr19:45726357-46331629 (+)
C3H/HeJ	MGP_C3HHeJ_G0024969	protein coding gene	Chr19:47326250-47949120 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025652	protein coding gene	Chr19:49219092-49874159 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023065	protein coding gene	Chr19:44867032-45460215 (+)
CAST/EiJ	MGP_CASTEiJ_G0024434	protein coding gene	Chr19:47160652-47831830 (+)
CBA/J	MGP_CBAJ_G0024949	protein coding gene	Chr19:51700404-52390698 (+)
DBA/2J	MGP_DBA2J_G0025081	protein coding gene	Chr19:45489554-46105578 (+)
FVB/NJ	MGP_FVBNJ_G0025042	protein coding gene	Chr19:45258798-45857739 (+)
LP/J	MGP_LPJ_G0025167	protein coding gene	Chr19:47978286-48605770 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025073	protein coding gene	Chr19:50916605-51565979 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025710	protein coding gene	Chr19:47281791-47905008 (+)
PWK/PhJ	MGP_PWKPhJ_G0024183	protein coding gene	Chr19:45451913-46087881 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023986	protein coding gene	Chr19:45940986-46580791 (+)
WSB/EiJ	MGP_WSBEiJ_G0024504	protein coding gene	Chr19:47430555-48056881 (+)

Human Ortholog

SORCS3, sortilin related VPS10 domain containing receptor 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SORCS3, sortilin related VPS10 domain containing receptor 3
Synonyms

SORCS
Links

HGNC:16699

NCBI Gene ID: 22986

neXtProt AC: NX_Q9UPU3

UniProt: Q9UPU3
Chr Location

10q25.1; chr10:104641290-105265242 (+) GRCh38

MGI Vertebrate Homology

Sorcs3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SORCS3
Gene Tree

Sorcs3

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

65 strains or lines available

Mice homozygous for a knock-out allele exhibit absent NMDA and glutamate receptor-dependent long term depression, impaired spatial learning and memory and impaired fear memory.

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All GO Annotations

16
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

922
Tissues

105
cDNA Data

12
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sorcs3

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All Sequences

36
RefSeq

2
UniProt

2
CCDS

CCDS38020.1

Ensembl

ENSMUSG00000063434 (Evidence)
NCBI Gene

66673

			Length	Strain/Species	Flank
genomic	66673	NCBI Gene Model \| MGI Sequence Detail	599481	C57BL/6J	± kb
transcript	NM_025696	RefSeq \| MGI Sequence Detail	5634	C57BL/6
polypeptide	Q8VI51	UniProt \| EBI \| MGI Sequence Detail	1219	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030921 VPS10 domain-containing receptor SorCS3

(term hierarchy)
InterPro Domains

IPR013783 Immunoglobulin-like fold

IPR000601 PKD domain

IPR035986 PKD domain superfamily

IPR031777 Sortilin, C-terminal

IPR031778 Sortilin, N-terminal

IPR006581 VPS10

IPR050310 VPS10-related sortilin family receptors

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

Q8VI51 8 sites, 5 N-linked glycans (4 sites), 1 O-linked glycan (1 site)

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All nucleic 12

cDNA 12

Microarray probesets 5

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MGI:2147683

Summaries

All 28

Developmental Gene Expression 4

Gene Ontology 2

Phenotypes 4
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:286533 Tenney AP, et al., Etv1 Controls the Establishment of Non-overlapping Motor Innervation of Neighboring Facial Muscles during Development. Cell Rep. 2019 Oct 8;29(2):437-452.e4

TSS for Sorcs3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156922	Chr19:48193916-48193950 (+)	-531 bp
Tssr156923	Chr19:48193952-48193964 (+)	-506 bp
Tssr156924	Chr19:48194572-48194602 (+)	123 bp
Tssr156925	Chr19:48301785-48301790 (+)	107,324 bp
Tssr156926	Chr19:48320615-48320623 (+)	126,155 bp
Tssr5546	Chr19:48757938-48757941 (+)	563,476 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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