Tbc1d15 MGI Mouse Gene Detail - MGI:1913937 - TBC1 domain family, member 15

Symbol

Tbc1d15
Name

TBC1 domain family, member 15
Synonyms

4432405K22Rik, Ly6dl

Feature Type

protein coding gene
IDs

MGI:1913937
NCBI Gene: 66687
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:115033777-115087372 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 63.51 cM
Mapping Data

2 experiments

SNPs within 2kb

1467 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913937	protein coding gene	Chr10:115031459-115087372 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017734	protein coding gene	Chr10:117884990-117944519 (-)
A/J	MGP_AJ_G0017710	protein coding gene	Chr10:113368118-113424053 (-)
AKR/J	MGP_AKRJ_G0017672	protein coding gene	Chr10:116661045-116716963 (-)
BALB/cJ	MGP_BALBcJ_G0017673	protein coding gene	Chr10:113762872-113817480 (-)
C3H/HeJ	MGP_C3HHeJ_G0017498	protein coding gene	Chr10:116871064-116933065 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018130	protein coding gene	Chr10:121987811-122045410 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015810	protein coding gene	Chr10:107996533-108053509 (-)
CAST/EiJ	MGP_CASTEiJ_G0017060	protein coding gene	Chr10:117097239-117160896 (-)
CBA/J	MGP_CBAJ_G0017467	protein coding gene	Chr10:126741228-126799439 (-)
DBA/2J	MGP_DBA2J_G0017572	protein coding gene	Chr10:112520322-112574704 (-)
FVB/NJ	MGP_FVBNJ_G0017567	protein coding gene	Chr10:111466969-111520746 (-)
LP/J	MGP_LPJ_G0017647	protein coding gene	Chr10:118477447-118534479 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017596	protein coding gene	Chr10:129705567-129763612 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018168	protein coding gene	Chr10:116680630-116737415 (-)
PWK/PhJ	MGP_PWKPhJ_G0016842	protein coding gene	Chr10:112585868-112640100 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016632	protein coding gene	Chr10:115485706-115544618 (-)
WSB/EiJ	MGP_WSBEiJ_G0017120	protein coding gene	Chr10:116857963-116914685 (-)

Human Ortholog

TBC1D15, TBC1 domain family member 15

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TBC1D15, TBC1 domain family member 15
Synonyms

RAB7-GAP
Links

HGNC:25694

NCBI Gene ID: 64786

neXtProt AC: NX_Q8TC07

UniProt: Q8TC07
Chr Location

12q21.1; chr12:71839707-71927248 (+) GRCh38

MGI Vertebrate Homology

Tbc1d15 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TBC1D15
Gene Tree

Tbc1d15

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Phenotype Summary

6 phenotypes from 2 alleles in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

62
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

52
Targeted

5
Genomic Mutations

1 involving Tbc1d15
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

106 strains or lines available

Mice with loss of expression in the heart display increased susceptibility to ischemia/reperfusion induced injury.

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

6
cDNA Data

243
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tbc1d15

ZFIN tbc1d15

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All Sequences

70
RefSeq

10
UniProt

5
CCDS

CCDS24176.1

Ensembl

ENSMUSG00000020130 (Evidence)
NCBI Gene

66687

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020130	Ensembl Gene Model \| MGI Sequence Detail	53596	C57BL/6J	± kb
transcript	ENSMUST00000020339	Ensembl \| MGI Sequence Detail	3752	Not Applicable
polypeptide	ENSMUSP00000020339	Ensembl \| MGI Sequence Detail	671	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016099 TBC1 domain family member 15

(term hierarchy)
InterPro Domains

IPR000195 Rab-GAP-TBC domain

IPR035969 Rab-GAP-TBC domain superfamily

IPR021935 Small G protein signalling modulator 1/2, Rab-binding domain
GlyGen

Q9CXF4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 243

cDNA 243

Microarray probesets 6

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MGI:1913163, MGI:2143746, MGI:2143751, MGI:2143870

Summaries

All 45

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 18
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345582 Choi HY, et al., NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells. Exp Mol Med. 2024 Feb;56(2):461-477

TSS for Tbc1d15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99309	Chr10:115087312-115087369 (-)	31 bp
Tssr3358	Chr10:115087282-115087294 (-)	84 bp
Tssr99308	Chr10:115086436-115086445 (-)	931 bp
Tssr99307	Chr10:115086411-115086422 (-)	955 bp
Tssr99306	Chr10:115058609-115058617 (-)	28,759 bp
Tssr99305	Chr10:115058596-115058607 (-)	28,770 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24