Nkapl MGI Mouse Gene Detail - MGI:1913957 - NFKB activating protein-like

Symbol

Nkapl
Name

NFKB activating protein-like
Synonyms

4921504I05Rik

Feature Type

protein coding gene
IDs

MGI:1913957
NCBI Gene: 66707
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:21651217-21652671 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 7.81 cM, cytoband A3.1
Mapping Data

3 experiments

SNPs within 2kb

109 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913957	protein coding gene	Chr13:21651217-21652679 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020277	protein coding gene	Chr13:18732024-18733486 (-)
A/J	MGP_AJ_G0020233	protein coding gene	Chr13:18323160-18324622 (-)
AKR/J	MGP_AKRJ_G0020209	protein coding gene	Chr13:18628597-18630059 (-)
BALB/cJ	MGP_BALBcJ_G0020221	protein coding gene	Chr13:18378943-18380405 (-)
C3H/HeJ	MGP_C3HHeJ_G0020022	protein coding gene	Chr13:18719716-18721178 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020665	protein coding gene	Chr13:19399533-19400995 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018272	protein coding gene	Chr13:16668494-16669958 (-)
CAST/EiJ	MGP_CASTEiJ_G0019559	protein coding gene	Chr13:18527190-18528658 (-)
CBA/J	MGP_CBAJ_G0019986	protein coding gene	Chr13:20068347-20069809 (-)
DBA/2J	MGP_DBA2J_G0020107	protein coding gene	Chr13:17960769-17962231 (-)
FVB/NJ	MGP_FVBNJ_G0020089	protein coding gene	Chr13:17626396-17627858 (-)
LP/J	MGP_LPJ_G0020178	protein coding gene	Chr13:18978781-18980243 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020127	protein coding gene	Chr13:20455734-20457196 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020693	protein coding gene	Chr13:18443351-18444813 (-)
PWK/PhJ	MGP_PWKPhJ_G0019322	protein coding gene	Chr13:18006452-18007914 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019128	protein coding gene	Chr13:17458697-17460165 (-)
WSB/EiJ	MGP_WSBEiJ_G0019616	protein coding gene	Chr13:18526168-18527630 (-)

Human Ortholog

NKAPL, NFKB activating protein like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NKAPL, NFKB activating protein like
Synonyms

bA424I5.1, C6orf194
Links

HGNC:21584

NCBI Gene ID: 222698

neXtProt AC: NX_Q5M9Q1

UniProt: Q5M9Q1
Chr Location

6p22.1; chr6:28259297-28260958 (+) GRCh38

MGI Vertebrate Homology

Nkapl stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NKAPL
Gene Tree

Nkapl

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Nkapl
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit male infertility associated with arrested male meiosis, male germ cell apoptosis and azzospermia.

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

4
cDNA Data

15
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

2
UniProt

1
CCDS

CCDS26276.1

Ensembl

ENSMUSG00000059395 (Evidence)
NCBI Gene

66707

			Length	Strain/Species	Flank
genomic	66707	NCBI Gene Model \| MGI Sequence Detail	1455	C57BL/6J	± kb
transcript	NM_025719	RefSeq \| MGI Sequence Detail	1455	C57BL/6
polypeptide	Q5SZT7	UniProt \| EBI \| MGI Sequence Detail	395	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR040466 NF-kappa-B-activating protein

IPR009269 NF-kappa-B-activating protein, C-terminal

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All nucleic 17

Genomic 1

cDNA 15

Primer pair 1

Microarray probesets 2

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 12
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:229252 Okuda H, et al., A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis. PLoS One. 2015;10(4):e0124293

TSS for Nkapl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121662	Chr13:21652680-21652721 (-)	-30 bp
Tssr121661	Chr13:21652644-21652678 (-)	10 bp
Tssr121660	Chr13:21652633-21652643 (-)	33 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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