Grtp1 MGI Mouse Gene Detail - MGI:1914040 - GH regulated TBC protein 1

Symbol

Grtp1
Name

GH regulated TBC protein 1
Synonyms

5430401C05Rik, Tbc1d6

Feature Type

protein coding gene
IDs

MGI:1914040
NCBI Gene: 66790
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:13226869-13250695 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 5.73 cM
Mapping Data

2 experiments

SNPs within 2kb

708 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914040	protein coding gene	Chr8:13222022-13250695 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033374	protein coding gene	Chr8:10503342-10527978 (-)
A/J	MGP_AJ_G0033354	protein coding gene	Chr8:10129816-10153376 (-)
AKR/J	MGP_AKRJ_G0033285	protein coding gene	Chr8:10395056-10423032 (-)
BALB/cJ	MGP_BALBcJ_G0033355	protein coding gene	Chr8:10262786-10286379 (-)
C3H/HeJ	MGP_C3HHeJ_G0033068	protein coding gene	Chr8:10611609-10636316 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033867	protein coding gene	Chr8:10871227-10901526 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030836	protein coding gene	Chr8:9633107-9656628 (-)
CAST/EiJ	MGP_CASTEiJ_G0032390	protein coding gene	Chr8:10362023-10387431 (-)
CBA/J	MGP_CBAJ_G0033041	protein coding gene	Chr8:11323535-11348509 (-)
DBA/2J	MGP_DBA2J_G0033194	protein coding gene	Chr8:10079809-10103590 (-)
FVB/NJ	MGP_FVBNJ_G0033143	protein coding gene	Chr8:10091537-10116496 (-)
LP/J	MGP_LPJ_G0033288	protein coding gene	Chr8:10417272-10442430 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033177	protein coding gene	Chr8:11567330-11592286 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033884	protein coding gene	Chr8:10459122-10483560 (-)
PWK/PhJ	MGP_PWKPhJ_G0032103	protein coding gene	Chr8:10127771-10152010 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031945	protein coding gene	Chr8:10351821-10381309 (-)
WSB/EiJ	MGP_WSBEiJ_G0032506	protein coding gene	Chr8:10490836-10515818 (-)

Human Ortholog

GRTP1, growth hormone regulated TBC protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GRTP1, growth hormone regulated TBC protein 1
Synonyms

TBC1D6
Links

HGNC:20310

NCBI Gene ID: 79774

neXtProt AC: NX_Q5TC63

UniProt: Q5TC63
Chr Location

13q34; chr13:113324163-113364148 (-) GRCh38

MGI Vertebrate Homology

Grtp1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GRTP1
Gene Tree

Grtp1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Gene trapped

19
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

870
Tissues

72
cDNA Data

40
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase grtp1

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All Sequences

58
RefSeq

12
UniProt

4
CCDS

CCDS22107.1, CCDS90375.1

Ensembl

ENSMUSG00000038515 (Evidence)
NCBI Gene

66790

			Length	Strain/Species	Flank
genomic	66790	NCBI Gene Model \| MGI Sequence Detail	23827	C57BL/6J	± kb
transcript	NM_001368858	RefSeq \| MGI Sequence Detail	1361	C57BL/6
polypeptide	Q9D3N8	UniProt \| EBI \| MGI Sequence Detail	359	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008276 growth hormone-regulated TBC protein 1

(term hierarchy)
InterPro Domains

IPR000195 Rab-GAP-TBC domain

IPR035969 Rab-GAP-TBC domain superfamily

IPR050302 Rab GTPase-activating TBC domain-containing protein

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All nucleic 44

cDNA 43

Primer pair 1

Microarray probesets 3

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MGI:2142862

Summaries

All 37

Developmental Gene Expression 6

Gene Ontology 2

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Grtp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr80428	Chr8:13250576-13250636 (-)	89 bp
Tssr80427	Chr8:13248142-13248145 (-)	2,551 bp
Tssr80426	Chr8:13242362-13242366 (-)	8,331 bp
Tssr2497	Chr8:13242354-13242359 (-)	8,338 bp
Tssr80425	Chr8:13242288-13242336 (-)	8,383 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24