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Hmces Gene Detail
Summary
  • Symbol
    Hmces
  • Name
    5-hydroxymethylcytosine (hmC) binding, ES cell specific
  • Synonyms
    8430410A17Rik, Srap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914053
    NCBI Gene: 232210
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:87890917-87913611 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 39.13 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    802 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914053
 protein coding gene Chr6:87890889-87913611 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031003
 protein coding gene Chr6:89287261-89312452 (+)
A/J MGP_AJ_G0030969
 protein coding gene Chr6:85843438-85866846 (+)
AKR/J MGP_AKRJ_G0030900
 protein coding gene Chr6:88323145-88345841 (+)
BALB/cJ MGP_BALBcJ_G0030982
 protein coding gene Chr6:85833400-85856116 (+)
C3H/HeJ MGP_C3HHeJ_G0030728
 protein coding gene Chr6:96125080-96148719 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031439
 protein coding gene Chr6:91674072-91697590 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028622
 protein coding gene Chr6:84014021-84038047 (+)
CAST/EiJ MGP_CASTEiJ_G0030091
 protein coding gene Chr6:88401820-88426448 (+)
CBA/J MGP_CBAJ_G0030666
 protein coding gene Chr6:95222033-95244695 (+)
DBA/2J MGP_DBA2J_G0030822
 protein coding gene Chr6:85138290-85160940 (+)
FVB/NJ MGP_FVBNJ_G0030775
 protein coding gene Chr6:84329011-84352117 (+)
LP/J MGP_LPJ_G0030899
 protein coding gene Chr6:89303633-89326139 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030808
 protein coding gene Chr6:99354739-99378130 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031466
 protein coding gene Chr6:88176688-88203185 (+)
PWK/PhJ MGP_PWKPhJ_G0029806
 protein coding gene Chr6:84110223-84133232 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029634
 protein coding gene Chr6:86986528-87010769 (+)
WSB/EiJ MGP_WSBEiJ_G0030172
 protein coding gene Chr6:88624430-88651486 (+)



Homology
more
  • Human Ortholog
    HMCES, 5-hydroxymethylcytosine binding, ES cell specific
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMCES, 5-hydroxymethylcytosine binding, ES cell specific
  • Synonyms
    C3orf37, DC12, SRAPD1
  • Links
    NCBI Gene ID: 56941
    neXtProt AC: NX_Q96FZ2
    UniProt: Q96FZ2

  • Chr Location
    3q21.3; chr3:129278828-129306186 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout leads to changes in DNA methylation, resulting in an altered embryonic gene expression profile and embryonic sub-lethality (lower embryonic survival).
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    14
  • cDNA Data
    65
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030060 Ensembl Gene Model | MGI Sequence Detail 22695 C57BL/6J ±  kb
transcript ENSMUST00000113606 Ensembl | MGI Sequence Detail 1572 Not Applicable  
polypeptide ENSMUSP00000109236 Ensembl | MGI Sequence Detail 353 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 66
    cDNA 65
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141771
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:344038 Pan Y, et al., HMCES safeguards genome integrity and long-term self-renewal of hematopoietic stem cells during stress responses. Leukemia. 2022 Jan 17;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory