Duoxa2 MGI Mouse Gene Detail - MGI:1914061 - dual oxidase maturation factor 2

Symbol

Duoxa2
Name

dual oxidase maturation factor 2
Synonyms

9030623N16Rik, Nip2

Feature Type

protein coding gene
IDs

MGI:1914061
NCBI Gene: 66811
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:122129381-122133088 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 60.62 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

166 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914061	protein coding gene	Chr2:122129381-122133366 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026411	protein coding gene	Chr2:125300597-125304578 (+)
A/J	MGP_AJ_G0026373	protein coding gene	Chr2:120174981-120179015 (+)
AKR/J	MGP_AKRJ_G0026350	protein coding gene	Chr2:123541488-123545523 (+)
BALB/cJ	MGP_BALBcJ_G0026385	protein coding gene	Chr2:120404663-120408697 (+)
C3H/HeJ	MGP_C3HHeJ_G0026130	protein coding gene	Chr2:124023824-124027858 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026832	protein coding gene	Chr2:129366877-129370863 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024211	protein coding gene	Chr2:115144918-115148891 (+)
CAST/EiJ	MGP_CASTEiJ_G0025592	protein coding gene	Chr2:124365068-124369045 (+)
CBA/J	MGP_CBAJ_G0026109	protein coding gene	Chr2:133917196-133921230 (+)
DBA/2J	MGP_DBA2J_G0026246	protein coding gene	Chr2:119571320-119575354 (+)
FVB/NJ	MGP_FVBNJ_G0026208	protein coding gene	Chr2:118364287-118368264 (+)
LP/J	MGP_LPJ_G0026348	protein coding gene	Chr2:125545850-125549856 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026228	protein coding gene	Chr2:138127791-138131766 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026887	protein coding gene	Chr2:123658720-123662757 (+)
PWK/PhJ	MGP_PWKPhJ_G0025328	protein coding gene	Chr2:119185040-119189057 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025128	protein coding gene	Chr2:122801874-122805910 (+)
WSB/EiJ	MGP_WSBEiJ_G0025664	protein coding gene	Chr2:124519698-124523668 (+)

Human Ortholog

DUOXA2, dual oxidase maturation factor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DUOXA2, dual oxidase maturation factor 2
Synonyms

SIMNIPHOM, TDH5
Links

HGNC:32698

NCBI Gene ID: 405753

neXtProt AC: NX_Q1HG44

UniProt: Q1HG44
Chr Location

15q21.1; chr15:45114326-45118421 (+) GRCh38

MGI Vertebrate Homology

Duoxa2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DUOXA2
Gene Tree

Duoxa2

Diseases

1 with human DUOXA2 associations

				Human Disease	Mouse Models
				thyroid dyshormonogenesis 5 IDs thyroid dyshormonogenesis 5 DOID:0112184 MESH:C562771 OMIM:274900

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

78 phenotypes from 1 allele in 1 genetic background
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

1
Targeted

3
Genomic Mutations

3 involving Duoxa2
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele of Duoxa1 and 2 exhibit severe hypothyrodism with severe postnatal growth, delayed eye opening, enlarged thyroid, enlarged adenohypophysis, respiratory distress and death at weaning when weaned at 21 days.

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All GO Annotations

25
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

717
Tissues

11
cDNA Data

7
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

29
RefSeq

2
UniProt

1
CCDS

CCDS16660.1

Ensembl

ENSMUSG00000027225 (Evidence)
NCBI Gene

66811

			Length	Strain/Species	Flank
genomic	66811	NCBI Gene Model \| MGI Sequence Detail	3708	C57BL/6J	± kb
transcript	NM_025777	RefSeq \| MGI Sequence Detail	1314	C57BL/6
polypeptide	Q9D311	UniProt \| EBI \| MGI Sequence Detail	320	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006730 dual oxidase maturation factor 2

(term hierarchy)
InterPro Domains

IPR018469 Dual oxidase maturation factor
GlyGen

Q9D311 3 sites

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All nucleic 8

cDNA 7

Primer pair 1

Microarray probesets 3

Summaries

All 54

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 26
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Duoxa2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19840	Chr2:122129379-122129384 (+)	1 bp
Tssr19841	Chr2:122131612-122131631 (+)	2,241 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24