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Ppcdc Gene Detail
Summary
  • Symbol
    Ppcdc
  • Name
    phosphopantothenoylcysteine decarboxylase
  • Synonyms
    1810057I13Rik, 8430432M10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914062
    NCBI Gene: 66812
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:57292378-57347407 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 31.04 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1350 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914062
 protein coding gene Chr9:57292378-57347440 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034864
 protein coding gene Chr9:56618942-56643819 (-)
A/J MGP_AJ_G0034845
 protein coding gene Chr9:54794028-54821358 (-)
AKR/J MGP_AKRJ_G0034774
 protein coding gene Chr9:56056757-56081263 (-)
BALB/cJ MGP_BALBcJ_G0034837
 protein coding gene Chr9:54571769-54600337 (-)
C3H/HeJ MGP_C3HHeJ_G0034547
 protein coding gene Chr9:56535326-56562715 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035356
 protein coding gene Chr9:58205183-58234159 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032267
 protein coding gene Chr9:54110874-54134519 (-)
CAST/EiJ MGP_CASTEiJ_G0033868
 protein coding gene Chr9:56617031-56646618 (-)
CBA/J MGP_CBAJ_G0034518
 protein coding gene Chr9:60232869-60262738 (-)
DBA/2J MGP_DBA2J_G0034677
 protein coding gene Chr9:54662150-54689840 (-)
FVB/NJ MGP_FVBNJ_G0034619
 protein coding gene Chr9:53884932-53912547 (-)
LP/J MGP_LPJ_G0034760
 protein coding gene Chr9:56916780-56944804 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034662
 protein coding gene Chr9:61731137-61761087 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035378
 protein coding gene Chr9:56075450-56103156 (-)
PWK/PhJ MGP_PWKPhJ_G0033573
 protein coding gene Chr9:54697355-54724465 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033407
 protein coding gene Chr9:56362870-56393712 (-)
WSB/EiJ MGP_WSBEiJ_G0033981
 protein coding gene Chr9:56007608-56033803 (-)



Homology
more
  • Human Ortholog
    PPCDC, phosphopantothenoylcysteine decarboxylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPCDC, phosphopantothenoylcysteine decarboxylase
  • Synonyms
    coaC, MDS018, PPC-DC
  • Links
    NCBI Gene ID: 60490
    neXtProt AC: NX_Q96CD2
    UniProt: Q96CD2

  • Chr Location
    15q24.2; chr15:75023586-75117462 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    64
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063849 Ensembl Gene Model | MGI Sequence Detail 55030 C57BL/6J ±  kb
transcript ENSMUST00000085709 Ensembl | MGI Sequence Detail 2744 Not Applicable  
polypeptide ENSMUSP00000082856 Ensembl | MGI Sequence Detail 204 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 64
    cDNA 64

    Microarray probesets 5
Other
Accession IDs
less
MGI:1919287
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:336442 Bravo-Alonso I, et al., Pathogenic variants of the coenzyme A biosynthesis-associated enzyme phosphopantothenoylcysteine decarboxylase cause autosomal-recessive dilated cardiomyopathy. J Inherit Metab Dis. 2023 Mar;46(2):261-272
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory