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Rnf186 Gene Detail
Summary
  • Symbol
    Rnf186
  • Name
    ring finger protein 186
  • Synonyms
    9130020G10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914075
    NCBI Gene: 66825
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:138694430-138695676 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 70.57 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    126 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914075
 protein coding gene Chr4:138694423-138695676 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029008
 protein coding gene Chr4:141772973-141774221 (+)
A/J MGP_AJ_G0028967
 protein coding gene Chr4:135679399-135680647 (+)
AKR/J MGP_AKRJ_G0028919
 protein coding gene Chr4:139568343-139569591 (+)
BALB/cJ MGP_BALBcJ_G0028991
 protein coding gene Chr4:136356653-136357901 (+)
C3H/HeJ MGP_C3HHeJ_G0028705
 protein coding gene Chr4:139940907-139942155 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029432
 protein coding gene Chr4:146793931-146795179 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026703
 protein coding gene Chr4:128653176-128654427 (+)
CAST/EiJ MGP_CASTEiJ_G0028137
 protein coding gene Chr4:138116829-138118077 (+)
CBA/J MGP_CBAJ_G0028669
 protein coding gene Chr4:151016963-151018211 (+)
DBA/2J MGP_DBA2J_G0028819
 protein coding gene Chr4:136065361-136066609 (+)
FVB/NJ MGP_FVBNJ_G0028786
 protein coding gene Chr4:135093947-135095195 (+)
LP/J MGP_LPJ_G0028918
 protein coding gene Chr4:141848245-141849493 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028812
 protein coding gene Chr4:154948860-154950108 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029470
 protein coding gene Chr4:140093538-140094786 (+)
PWK/PhJ MGP_PWKPhJ_G0027858
 protein coding gene Chr4:132925162-132926410 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027683
 protein coding gene Chr4:135856825-135858075 (+)
WSB/EiJ MGP_WSBEiJ_G0028215
 protein coding gene Chr4:140344708-140345956 (+)



Homology
more
  • Human Ortholog
    RNF186, ring finger protein 186
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF186, ring finger protein 186
  • Links
    NCBI Gene ID: 54546
    neXtProt AC: NX_Q9NXI6
    UniProt: Q9NXI6

  • Chr Location
    1p36.13; chr1:19814029-19815283 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Although mice homozygous for a null allele do not develop spontaneous colitis, they show increased permeability of organic solutes in the colon, disturbed protein homeostasis and enhanced endoplasmic reticulum stress in colonic epithelia, and increased susceptibility to induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    912
  • Tissues
    136
  • cDNA Data
    20
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66825 NCBI Gene Model | MGI Sequence Detail 1247 C57BL/6J ±  kb
    transcript NM_025786 RefSeq | MGI Sequence Detail 1247 C57BL/6  
    polypeptide Q9D241 UniProt | EBI | MGI Sequence Detail 226 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 3
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:344411 Du J, et al., Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non-alcoholic fatty liver disease. Metabolism. 2023 Dec 27;152:155769
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory