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Ttc1 Gene Detail
Summary
  • Symbol
    Ttc1
  • Name
    tetratricopeptide repeat domain 1
  • Synonyms
    4833412C19Rik, TPR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914077
    NCBI Gene: 66827
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:43620833-43638835 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 25.81 cM, cytoband B1.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    532 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914077
 protein coding gene Chr11:43620339-43638835 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018178
 protein coding gene Chr11:42514881-42535863 (-)
A/J MGP_AJ_G0018150
 protein coding gene Chr11:40891072-40912005 (-)
AKR/J MGP_AKRJ_G0018114
 protein coding gene Chr11:42091455-42109547 (-)
BALB/cJ MGP_BALBcJ_G0018119
 protein coding gene Chr11:41066930-41086735 (-)
C3H/HeJ MGP_C3HHeJ_G0017932
 protein coding gene Chr11:42122447-42141331 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018573
 protein coding gene Chr11:43799027-43817361 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016228
 protein coding gene Chr11:38945705-38965663 (-)
CAST/EiJ MGP_CASTEiJ_G0017496
 protein coding gene Chr11:42168380-42186505 (-)
CBA/J MGP_CBAJ_G0017905
 protein coding gene Chr11:45836689-45856833 (-)
DBA/2J MGP_DBA2J_G0018015
 protein coding gene Chr11:40667164-40686660 (-)
FVB/NJ MGP_FVBNJ_G0018009
 protein coding gene Chr11:40351817-40370416 (-)
LP/J MGP_LPJ_G0018087
 protein coding gene Chr11:42754788-42778873 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018033
 protein coding gene Chr11:47495407-47513994 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018612
 protein coding gene Chr11:42249366-42268618 (-)
PWK/PhJ MGP_PWKPhJ_G0017276
 protein coding gene Chr11:40696356-40718621 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017069
 protein coding gene Chr11:42042503-42062461 (-)
WSB/EiJ MGP_WSBEiJ_G0017545
 protein coding gene Chr11:41888504-41906604 (-)



Homology
more
  • Human Ortholog
    TTC1, tetratricopeptide repeat domain 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TTC1, tetratricopeptide repeat domain 1
  • Synonyms
    TPR1
  • Links
    NCBI Gene ID: 7265
    neXtProt AC: NX_Q99614
    UniProt: Q99614

  • Chr Location
    5q33.3; chr5:160009113-160065543 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    1 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths with a poorly defined inner cell mass after 3 days in culture.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    72
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66827 NCBI Gene Model | MGI Sequence Detail 18003 C57BL/6J ±  kb
    transcript NM_133795 RefSeq | MGI Sequence Detail 1467 C57BL/6  
    polypeptide Q91Z38 UniProt | EBI | MGI Sequence Detail 292 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000029832 tetratricopeptide repeat protein 1
      (term hierarchy)
    • InterPro Domains
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
      IPR052769 Tetratricopeptide repeat domain-containing protein
    • GlyGen
      Q91Z38 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 73

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144652
    References
    more
    • Summaries
      All 42
      Gene Ontology 2
      Phenotypes 16
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory