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Ormdl2 Gene Detail
Summary
  • Symbol
    Ormdl2
  • Name
    ORM1-like 2 (S. cerevisiae)
  • Synonyms
    0610012C09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914094
    NCBI Gene: 66844
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128653771-128657498 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 77.16 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    89 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914094
 protein coding gene Chr10:128653771-128657514 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017885
 protein coding gene Chr10:132611765-132615934 (-)
A/J MGP_AJ_G0017860
 protein coding gene Chr10:127273615-127278396 (-)
AKR/J MGP_AKRJ_G0017823
 protein coding gene Chr10:130989218-130993372 (-)
BALB/cJ MGP_BALBcJ_G0017824
 protein coding gene Chr10:127635120-127639312 (-)
C3H/HeJ MGP_C3HHeJ_G0017647
 protein coding gene Chr10:131160527-131164680 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018279
 protein coding gene Chr10:137078537-137082732 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015957
 protein coding gene Chr10:121184830-121188512 (-)
CAST/EiJ MGP_CASTEiJ_G0017208
 protein coding gene Chr10:131883518-131887671 (-)
CBA/J MGP_CBAJ_G0017617
 protein coding gene Chr10:142672907-142677061 (-)
DBA/2J MGP_DBA2J_G0017723
 protein coding gene Chr10:126328787-126332966 (-)
FVB/NJ MGP_FVBNJ_G0017718
 protein coding gene Chr10:125252420-125256622 (-)
LP/J MGP_LPJ_G0017797
 protein coding gene Chr10:133184438-133188604 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017746
 protein coding gene Chr10:145230422-145245168 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018319
 protein coding gene Chr10:131096443-131100640 (-)
PWK/PhJ MGP_PWKPhJ_G0016993
 protein coding gene Chr10:126598347-126602576 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016782
 protein coding gene Chr10:130203106-130208094 (-)
WSB/EiJ MGP_WSBEiJ_G0017267
 protein coding gene Chr10:131321679-131325830 (-)



Homology
more
  • Human Ortholog
    ORMDL2, ORMDL sphingolipid biosynthesis regulator 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ORMDL2, ORMDL sphingolipid biosynthesis regulator 2
  • Synonyms
    adoplin-2, HSPC160, MST095, MSTP095
  • Links
    NCBI Gene ID: 29095
    neXtProt AC: NX_Q53FV1
    UniProt: Q53FV1

  • Chr Location
    12q13.2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotypes from multigenic genotypes
    9 phenotype references
Mice homozygous for a null allele exhibit normal mast cell proliferation, degranulation, ceramide levels, and sphingosine levels, and response to passive cutaneous or systemic anaphylaxis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    11
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66844 NCBI Gene Model | MGI Sequence Detail 3728 C57BL/6J ±  kb
transcript NM_001359170 RefSeq | MGI Sequence Detail 1654 C57BL/6  
polypeptide Q9CQZ0 UniProt | EBI | MGI Sequence Detail 153 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:349248 Demkova L, et al., Simultaneous reduction of all ORMDL proteins decreases the threshold of mast cell activation. Sci Rep. 2023 Jun 14;13(1):9615
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory