Tanc1 MGI Mouse Gene Detail - MGI:1914110 - tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

Symbol

Tanc1
Name

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms

1200003E16Rik, mKIAA1728

Feature Type

protein coding gene
IDs

MGI:1914110
NCBI Gene: 66860
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr2:59442386-59676493 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 33.93 cM
Mapping Data

2 experiments

SNPs within 2kb

6962 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914110	protein coding gene	Chr2:59442167-59676557 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025756	protein coding gene	Chr2:59155126-59402784 (+)
A/J	MGP_AJ_G0025732	protein coding gene	Chr2:56870158-57108396 (+)
AKR/J	MGP_AKRJ_G0025702	protein coding gene	Chr2:58434848-58677625 (+)
BALB/cJ	MGP_BALBcJ_G0025727	protein coding gene	Chr2:56980816-57217040 (+)
C3H/HeJ	MGP_C3HHeJ_G0025488	protein coding gene	Chr2:58541965-58784285 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026174	protein coding gene	Chr2:60922763-61169087 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023578	protein coding gene	Chr2:54466243-54703486 (+)
CAST/EiJ	MGP_CASTEiJ_G0024952	protein coding gene	Chr2:58572252-58820062 (+)
CBA/J	MGP_CBAJ_G0025468	protein coding gene	Chr2:63224032-63481115 (+)
DBA/2J	MGP_DBA2J_G0025599	protein coding gene	Chr2:56488663-56725144 (+)
FVB/NJ	MGP_FVBNJ_G0025561	protein coding gene	Chr2:56028641-56267794 (+)
LP/J	MGP_LPJ_G0025687	protein coding gene	Chr2:59012732-59254281 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025592	protein coding gene	Chr2:64857570-65105391 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026231	protein coding gene	Chr2:58466613-58704771 (+)
PWK/PhJ	MGP_PWKPhJ_G0024693	protein coding gene	Chr2:56325256-56566355 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024500	protein coding gene	Chr2:58550870-58789423 (+)
WSB/EiJ	MGP_WSBEiJ_G0025020	protein coding gene	Chr2:58763969-59004898 (+)

Human Ortholog

TANC1, tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TANC1, tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms

ROLSB, TANC
Links

HGNC:29364

NCBI Gene ID: 85461

neXtProt AC: NX_Q9C0D5

UniProt: Q9C0D5
Chr Location

2q24.2; chr2:158968640-159232659 (+) GRCh38

MGI Vertebrate Homology

Tanc1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TANC1
Gene Tree

Tanc1

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

650
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

648
Genomic Mutations

1 involving Tanc1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

405 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap vector exhibit decreased spine density in the CA3 region and impaired spatial memory.

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All GO Annotations

12
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

750
Tissues

5
cDNA Data

18
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tanc1

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All Sequences

98
RefSeq

36
UniProt

6
CCDS

CCDS16054.1, CCDS71057.1

Ensembl

ENSMUSG00000035168 (Evidence)
NCBI Gene

66860

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035168	Ensembl Gene Model \| MGI Sequence Detail	234108	C57BL/6J	± kb
transcript	ENSMUST00000139863	Ensembl \| MGI Sequence Detail	7246	Not Applicable
polypeptide	ENSMUSP00000123345	Ensembl \| MGI Sequence Detail	1856	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000016046 protein TANC1

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR050889 Dendritic Spine Regulation and Scaffold

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat
GlyGen

Q0VGY8 6 sites, 1 O-linked glycan (6 sites)

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All nucleic 18

cDNA 18

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 15
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tanc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17861	Chr2:59442378-59442453 (+)	30 bp
Tssr17862	Chr2:59453344-59453348 (+)	10,960 bp
Tssr17863	Chr2:59460410-59460419 (+)	18,029 bp
Tssr17864	Chr2:59464643-59464647 (+)	22,259 bp
Tssr17865	Chr2:59470711-59470715 (+)	28,327 bp
Tssr17866	Chr2:59475838-59475841 (+)	33,454 bp
Tssr17867	Chr2:59486856-59486860 (+)	44,472 bp
Tssr17868	Chr2:59606373-59606398 (+)	164,000 bp
Tssr17869	Chr2:59606411-59606430 (+)	164,035 bp
Tssr17870	Chr2:59609832-59609850 (+)	167,455 bp
Tssr17871	Chr2:59610043-59610065 (+)	167,668 bp
Tssr17872	Chr2:59610071-59610087 (+)	167,693 bp
Tssr17873	Chr2:59636498-59636502 (+)	194,114 bp
Tssr17874	Chr2:59642068-59642077 (+)	199,687 bp
Tssr17875	Chr2:59642288-59642317 (+)	199,917 bp
Tssr17876	Chr2:59642358-59642385 (+)	199,986 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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