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Lztr1 Gene Detail
Summary
  • Symbol
    Lztr1
  • Name
    leucine-zipper-like transcriptional regulator, 1
  • Synonyms
    1200003E21Rik, TCFL2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914113
    NCBI Gene: 66863
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17326552-17344197 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 10.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    460 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914113
 protein coding gene Chr16:17326124-17344197 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022582
 protein coding gene Chr16:14662182-14683296 (+)
A/J MGP_AJ_G0022543
 protein coding gene Chr16:13936813-13954997 (+)
AKR/J MGP_AKRJ_G0022520
 protein coding gene Chr16:14485176-14502834 (+)
BALB/cJ MGP_BALBcJ_G0022546
 protein coding gene Chr16:14080928-14100807 (+)
C3H/HeJ MGP_C3HHeJ_G0022313
 protein coding gene Chr16:14633394-14651835 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022997
 protein coding gene Chr16:14895279-14911929 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020517
 protein coding gene Chr16:14004682-14022649 (+)
CAST/EiJ MGP_CASTEiJ_G0021841
 protein coding gene Chr16:14535101-14552588 (+)
CBA/J MGP_CBAJ_G0022284
 protein coding gene Chr16:15567179-15589863 (+)
DBA/2J MGP_DBA2J_G0022414
 protein coding gene Chr16:13855925-13873628 (+)
FVB/NJ MGP_FVBNJ_G0022390
 protein coding gene Chr16:13898504-13916349 (+)
LP/J MGP_LPJ_G0022481
 protein coding gene Chr16:14420200-14444732 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022411
 protein coding gene Chr16:15264633-15282263 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023008
 protein coding gene Chr16:14425039-14444615 (+)
PWK/PhJ MGP_PWKPhJ_G0021584
 protein coding gene Chr16:14108714-14126391 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021412
 protein coding gene Chr16:14406505-14427126 (+)
WSB/EiJ MGP_WSBEiJ_G0021888
 protein coding gene Chr16:14420770-14439389 (+)



Homology
more
  • Human Ortholog
    LZTR1, leucine zipper like post translational regulator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LZTR1, leucine zipper like post translational regulator 1
  • Synonyms
    BTBD29, LZTR-1, NS10, NS2, SWNTS2
  • Links
    NCBI Gene ID: 8216
    neXtProt AC: NX_Q8N653
    UniProt: Q8N653

  • Chr Location
    22q11.21; chr22:20982269-20999032 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lztr1 mouse models; 9 with human LZTR1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die between E17.5 and birth. Heterozygotes exhibit Noonan syndrome phenotypes, including decreased weight and facial dysmorphia in males and eccentric hypertrophy, enlarged myocardial fibers and premature death in both sexes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    971
  • Tissues
    197
  • cDNA Data
    15
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022761 Ensembl Gene Model | MGI Sequence Detail 17646 C57BL/6J ±  kb
    transcript ENSMUST00000023444 Ensembl | MGI Sequence Detail 3394 Not Applicable  
    polypeptide ENSMUSP00000023444 Ensembl | MGI Sequence Detail 837 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 15
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146460, MGI:2146657
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 11
      Diseases 2
      Gene Ontology 5
      Phenotypes 21
    • Earliest
      J:28008 Harrison SM, et al., Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Development. 1995 Aug;121(8):2479-89
    • Latest
      J:348704 Vong KI, et al., Risk of meningomyelocele mediated by the common 22q11.2 deletion. Science. 2024 May 3;384(6695):584-590
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory