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Tril Gene Detail
Summary
  • Symbol
    Tril
  • Name
    TLR4 interactor with leucine-rich repeats
  • Synonyms
    1200009O22Rik, mKIAA0644
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914123
    NCBI Gene: 66873
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:53792453-53797810 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 26.07 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    199 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914123
 protein coding gene Chr6:53792453-53797815 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030756
 protein coding gene Chr6:53144419-53149780 (-)
A/J MGP_AJ_G0030725
 protein coding gene Chr6:50667711-50673069 (-)
AKR/J MGP_AKRJ_G0030652
 protein coding gene Chr6:52399628-52404987 (-)
BALB/cJ MGP_BALBcJ_G0030737
 protein coding gene Chr6:51020775-51026133 (-)
C3H/HeJ MGP_C3HHeJ_G0030450
 protein coding gene Chr6:52420932-52426293 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031192
 protein coding gene Chr6:54326715-54332077 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028398
 protein coding gene Chr6:48282859-48288166 (-)
CAST/EiJ MGP_CASTEiJ_G0029853
 protein coding gene Chr6:52255565-52260924 (-)
CBA/J MGP_CBAJ_G0030424
 protein coding gene Chr6:56571390-56576751 (-)
DBA/2J MGP_DBA2J_G0030574
 protein coding gene Chr6:50576679-50582040 (-)
FVB/NJ MGP_FVBNJ_G0030526
 protein coding gene Chr6:50166642-50172009 (-)
LP/J MGP_LPJ_G0030659
 protein coding gene Chr6:53092860-53098221 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030560
 protein coding gene Chr6:59126140-59131510 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031222
 protein coding gene Chr6:52334566-52339927 (-)
PWK/PhJ MGP_PWKPhJ_G0029566
 protein coding gene Chr6:50217616-50222966 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029400
 protein coding gene Chr6:51701370-51706757 (-)
WSB/EiJ MGP_WSBEiJ_G0029930
 protein coding gene Chr6:52357873-52363240 (-)



Homology
more
  • Human Ortholog
    TRIL, TLR4 interactor with leucine rich repeats
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIL, TLR4 interactor with leucine rich repeats
  • Links
    NCBI Gene ID: 9865
    neXtProt AC: NX_Q7L0X0
    UniProt: Q7L0X0

  • Chr Location
    7p14.3; chr7:28953358-28958330 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and behaviorally normal but show impaired cytokine production in the brain following intracranial LPS challenge and intraperitoneal E.coli infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    16
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    7
  • cDNA Data
    9
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66873 NCBI Gene Model | MGI Sequence Detail 5358 C57BL/6J ±  kb
transcript NM_025817 RefSeq | MGI Sequence Detail 5377 C57BL/6  
polypeptide Q9DBY4 UniProt | EBI | MGI Sequence Detail 809 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000032589 TLR4 interactor with leucine rich repeats
    (term hierarchy)
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR036116 Fibronectin type III superfamily
    IPR001611 Leucine-rich repeat
    IPR050541 Leucine-rich repeat and transmembrane domain-containing protein
    IPR032675 Leucine-rich repeat domain superfamily
    IPR003591 Leucine-rich repeat, typical subtype
  • GlyGen
    Q9DBY4 5 sites, 4 N-linked glycans (3 sites)
Molecular
Reagents
less
  • All nucleic 11
    cDNA 9
    Primer pair 1
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1353585
References
more
  • Summaries
    All 33
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 1
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:325730 Ahuja N, et al., Endothelial Cyp26b1 restrains murine heart valve growth during development. Dev Biol. 2022 Jun;486:81-95
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory