Lman2 MGI Mouse Gene Detail - MGI:1914140 - lectin, mannose-binding 2

Symbol

Lman2
Name

lectin, mannose-binding 2
Synonyms

1110003H06Rik, 1300009F09Rik, GP36B, VIP36

Feature Type

protein coding gene
IDs

MGI:1914140
NCBI Gene: 66890
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr13:55491646-55510596 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 29.80 cM
Mapping Data

2 experiments

SNPs within 2kb

541 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914140	protein coding gene	Chr13:55491646-55510596 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020592	protein coding gene	Chr13:54813832-54838933 (-)
A/J	MGP_AJ_G0020546	protein coding gene	Chr13:52792312-52812015 (-)
AKR/J	MGP_AKRJ_G0020524	protein coding gene	Chr13:54347860-54366621 (-)
BALB/cJ	MGP_BALBcJ_G0020542	protein coding gene	Chr13:53021879-53041131 (-)
C3H/HeJ	MGP_C3HHeJ_G0020341	protein coding gene	Chr13:54163567-54184380 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020976	protein coding gene	Chr13:56470218-56489113 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018558	protein coding gene	Chr13:50742113-50760392 (-)
CAST/EiJ	MGP_CASTEiJ_G0019855	protein coding gene	Chr13:54261556-54282696 (-)
CBA/J	MGP_CBAJ_G0020301	protein coding gene	Chr13:58629002-58655451 (-)
DBA/2J	MGP_DBA2J_G0020424	protein coding gene	Chr13:52343839-52364094 (-)
FVB/NJ	MGP_FVBNJ_G0020403	protein coding gene	Chr13:51814732-51833570 (-)
LP/J	MGP_LPJ_G0020500	protein coding gene	Chr13:55075894-55096754 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020432	protein coding gene	Chr13:58108992-58129858 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021019	protein coding gene	Chr13:53936762-53956588 (-)
PWK/PhJ	MGP_PWKPhJ_G0019611	protein coding gene	Chr13:52370887-52390413 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019438	protein coding gene	Chr13:52854642-52875633 (-)
WSB/EiJ	MGP_WSBEiJ_G0019917	protein coding gene	Chr13:54291133-54314243 (-)

Human Ortholog

LMAN2, lectin, mannose binding 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LMAN2, lectin, mannose binding 2
Synonyms

C5orf8, GP36B, VIP36
Links

HGNC:16986

NCBI Gene ID: 10960

neXtProt AC: NX_Q12907

UniProt: Q12907
Chr Location

5q35.3; chr5:177315805-177351840 (-) GRCh38

MGI Vertebrate Homology

Lman2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LMAN2
Gene Tree

Lman2

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

10
Targeted

2
Genomic Mutations

2 involving Lman2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

27
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

335

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lman2

ZFIN lman2

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All Sequences

95
RefSeq

2
UniProt

1
CCDS

CCDS26544.1

Ensembl

ENSMUSG00000021484 (Evidence)
NCBI Gene

66890

			Length	Strain/Species	Flank
genomic	66890	NCBI Gene Model \| MGI Sequence Detail	18951	C57BL/6J	± kb
transcript	NM_025828	RefSeq \| MGI Sequence Detail	4315	C57BL/6
polypeptide	Q9DBH5	UniProt \| EBI \| MGI Sequence Detail	358	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009852 vesicular integral-membrane protein VIP36

(term hierarchy)
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR051136 Intracellular Lectin and Glycoprotein Transporter

IPR005052 Legume-like lectin

IPR035664 VIP36, lectin domain
GlyGen

Q9DBH5 2 sites, 6 N-linked glycans (1 site), 1 O-linked glycan (1 site)

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All nucleic 336

cDNA 336

Microarray probesets 6

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MGI:1915811, MGI:2145146, MGI:2145322, MGI:2145368

Summaries

All 42

Diseases 1

Gene Ontology 6

Phenotypes 14
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Lman2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122689	Chr13:55510635-55510646 (-)	-45 bp
Tssr122688	Chr13:55510623-55510634 (-)	-33 bp
Tssr122687	Chr13:55510595-55510617 (-)	-10 bp
Tssr122686	Chr13:55510400-55510443 (-)	174 bp
Tssr122685	Chr13:55497752-55497756 (-)	12,842 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24