Cdca7 MGI Mouse Gene Detail - MGI:1914203 - cell division cycle associated 7

Symbol

Cdca7
Name

cell division cycle associated 7
Synonyms

2310021G01Rik, JPO1

Feature Type

protein coding gene
IDs

MGI:1914203
NCBI Gene: 66953
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:72306540-72317237 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 43.35 cM
Mapping Data

2 experiments

SNPs within 2kb

321 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914203	protein coding gene	Chr2:72306503-72317237 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025830	protein coding gene	Chr2:72665841-72676224 (+)
A/J	MGP_AJ_G0025808	protein coding gene	Chr2:69811763-69822450 (+)
AKR/J	MGP_AKRJ_G0025776	protein coding gene	Chr2:71751936-71762713 (+)
BALB/cJ	MGP_BALBcJ_G0025802	protein coding gene	Chr2:70025882-70036392 (+)
C3H/HeJ	MGP_C3HHeJ_G0025562	protein coding gene	Chr2:71938097-71950489 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026249	protein coding gene	Chr2:74845244-74860640 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023652	protein coding gene	Chr2:67051255-67061632 (+)
CAST/EiJ	MGP_CASTEiJ_G0025026	protein coding gene	Chr2:72147146-72157880 (+)
CBA/J	MGP_CBAJ_G0025543	protein coding gene	Chr2:77588086-77598805 (+)
DBA/2J	MGP_DBA2J_G0025674	protein coding gene	Chr2:69440904-69452201 (+)
FVB/NJ	MGP_FVBNJ_G0025636	protein coding gene	Chr2:68851363-68862759 (+)
LP/J	MGP_LPJ_G0025762	protein coding gene	Chr2:72549894-72560273 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025667	protein coding gene	Chr2:79536410-79548860 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026306	protein coding gene	Chr2:71822981-71833699 (+)
PWK/PhJ	MGP_PWKPhJ_G0024767	protein coding gene	Chr2:69327599-69338138 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024575	protein coding gene	Chr2:72031645-72044472 (+)
WSB/EiJ	MGP_WSBEiJ_G0025094	protein coding gene	Chr2:72279806-72290157 (+)

Human Ortholog

CDCA7, cell division cycle associated 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDCA7, cell division cycle associated 7
Synonyms

ICF3, JPO1
Links

HGNC:14628

NCBI Gene ID: 83879

neXtProt AC: NX_Q9BWT1

UniProt: Q9BWT1
Chr Location

2q31.1; chr2:173354820-173368997 (+) GRCh38

MGI Vertebrate Homology

Cdca7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDCA7
Gene Tree

Cdca7

Diseases

1 with human CDCA7 associations

				Human Disease	Mouse Models
				immunodeficiency-centromeric instability-facial anomalies syndrome 3 IDs immunodeficiency-centromeric instability-facial anomalies syndrome 3 DOID:0090010 ICD10CM:D84.8 OMIM:616910

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

9
Targeted

8
Genomic Mutations

7 involving Cdca7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available

Homozygosity for the p.G305V mutation reduces global DNA methylation levels and affects expression of various genes and gene clusters.

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All GO Annotations

9
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

837
Tissues

110
cDNA Data

149
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cdca7

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All Sequences

52
RefSeq

11
UniProt

2
CCDS

CCDS16121.1

Ensembl

ENSMUSG00000055612 (Evidence)
NCBI Gene

66953

			Length	Strain/Species	Flank
genomic	66953	NCBI Gene Model \| MGI Sequence Detail	10698	C57BL/6J	± kb
transcript	NM_001418562	RefSeq \| MGI Sequence Detail	2686	C57BL/6
polypeptide	Q9D0M2	UniProt \| EBI \| MGI Sequence Detail	382	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005224 cell division cycle-associated protein 7

(term hierarchy)
InterPro Domains

IPR040221 CDCA7/CDA7L

IPR018866 Zinc-finger domain of monoamine-oxidase A repressor R1

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All nucleic 153

cDNA 149

Primer pair 2

Other 2

Microarray probesets 3

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MGI:2146580

Summaries

All 63

Developmental Gene Expression 12

Gene Ontology 6

Phenotypes 20
Earliest

J:149 Morelli L, et al., Heterogeneity of natural killer cell subsets in NK-1.1+ and NK-1.1- inbred mouse strains and their progeny. Cell Immunol. 1992 Apr 15;141(1):148-60
Latest

J:345314 Vukic M, et al., CDCA7-associated global aberrant DNA hypomethylation translates to localized, tissue-specific transcriptional responses. Sci Adv. 2024 Feb 9;10(6):eadk3384

TSS for Cdca7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18351	Chr2:72306340-72306344 (+)	-198 bp
Tssr18352	Chr2:72306517-72306556 (+)	-3 bp
Tssr18353	Chr2:72306557-72306568 (+)	23 bp
Tssr18354	Chr2:72306569-72306603 (+)	46 bp
Tssr522	Chr2:72310376-72310392 (+)	3,844 bp
Tssr523	Chr2:72310423-72310426 (+)	3,885 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24