Swsap1 MGI Mouse Gene Detail - MGI:1914212 - SWIM type zinc finger 7 associated protein 1

Symbol

Swsap1
Name

SWIM type zinc finger 7 associated protein 1
Synonyms

2310047B19Rik

Feature Type

protein coding gene
IDs

MGI:1914212
NCBI Gene: 66962
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:21867051-21869560 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 7.93 cM, cytoband A4
Mapping Data

2 experiments

SNPs within 2kb

130 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914212	protein coding gene	Chr9:21867049-21869566 (+)
129S1/SvImJ	ENSMUSG00200044863	protein coding gene	Chr9:18821318-18823827 (+)
A/J	ENSMUSG00195033971	protein coding gene	Chr9:18657953-18660462 (+)
AKR/J	ENSMUSG00220031651	protein coding gene	Chr9:18660372-18662881 (+)
BALB/cJ	ENSMUSG00180040637	protein coding gene	Chr9:18792239-18794748 (+)
C3H/HeJ	ENSMUSG00175036474	protein coding gene	Chr9:18754773-18757282 (+)
C57BL/6NJ	ENSMUSG00215035740	protein coding gene	Chr9:18752065-18754575 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031889	protein coding gene	Chr9:17959595-17962151 (+)
CAST/EiJ	ENSTCUG00005026103	protein coding gene	Chr9:18798628-18801113 (+)
CBA/J	ENSMUSG00210037767	protein coding gene	Chr9:18735717-18738226 (+)
DBA/2J	ENSMUSG00185024688	protein coding gene	Chr9:18851006-18853515 (+)
FVB/NJ	ENSMUSG00205034664	protein coding gene	Chr9:19087044-19089552 (+)
JF1/MsJ	ENSUMUG00000044355	protein coding gene	Chr9:18952354-18954861 (+)
LP/J	ENSMUSG00230038156	protein coding gene	Chr9:19246238-19248747 (+)
NOD/ShiLtJ	ENSMUSG00190030504	protein coding gene	Chr9:18780006-18782515 (+)
NZO/HlLtJ	ENSMUSG00225048051	protein coding gene	Chr9:19192976-19195485 (+)
PWK/PhJ	ENSLUMG00010040690	protein coding gene	Chr9:18843461-18845971 (+)
SPRET/EiJ	ENSMSPG00010018832	protein coding gene	Chr9:19071683-19073312 (+)
WSB/EiJ	ENSIUOG00005044273	protein coding gene	Chr9:18321961-18324470 (+)

Human Ortholog

SWSAP1, SWIM-type zinc finger 7 associated protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SWSAP1, SWIM-type zinc finger 7 associated protein 1
Synonyms

C19orf39, SWS1AP1, ZSWIM7AP1
Links

HGNC:26638

NCBI Gene ID: 126074

UniProt: Q6NVH7
Chr Location

19p13.2; chr19:11374666-11376951 (+) GRCh38

MGI Vertebrate Homology

Swsap1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SWSAP1
Gene Tree

Swsap1

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Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotypes from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Gene trapped

4
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit female and male infertility with decreased testis and ovary weights, azoospermia, absent ovarian follicles and impaired chromosomal synapsis.

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All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

18

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase swsap1

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS52739.1

Ensembl

ENSMUSG00000051238 (Evidence)
NCBI Gene

66962

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051238	Ensembl Gene Model \| MGI Sequence Detail	2510	C57BL/6J	± kb
transcript	ENSMUST00000053583	Ensembl \| MGI Sequence Detail	1838	Not Applicable
polypeptide	ENSMUSP00000060331	Ensembl \| MGI Sequence Detail	278	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031405 ATPase SWSAP1

(term hierarchy)
EC

3.6.4.-
GlyGen

Q8VCI7 1 site

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All nucleic 18

cDNA 18

Microarray probesets 3

Summaries

All 36

Gene Ontology 6

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:359005 Zainu A, et al., FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading. Nat Commun. 2024 Aug 15;15(1):7015

TSS for Swsap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84059	Chr9:21867043-21867065 (+)	3 bp
Tssr84060	Chr9:21867067-21867095 (+)	30 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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