Ctu2 MGI Mouse Gene Detail - MGI:1914215 - cytosolic thiouridylase subunit 2

Symbol

Ctu2
Name

cytosolic thiouridylase subunit 2
Synonyms

2310061F22Rik

Feature Type

protein coding gene
IDs

MGI:1914215
NCBI Gene: 66965
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr8:123202882-123209831 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 71.26 cM
Mapping Data

1 experiment

SNPs within 2kb

225 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914215	protein coding gene	Chr8:123202882-123210877 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034228	protein coding gene	Chr8:126015803-126026969 (+)
A/J	MGP_AJ_G0034208	protein coding gene	Chr8:120801157-120808928 (+)
AKR/J	MGP_AKRJ_G0034135	protein coding gene	Chr8:124319773-124327426 (+)
BALB/cJ	MGP_BALBcJ_G0034202	protein coding gene	Chr8:121002240-121009917 (+)
C3H/HeJ	MGP_C3HHeJ_G0033913	protein coding gene	Chr8:125017621-125025690 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034722	protein coding gene	Chr8:130218150-130227420 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031664	protein coding gene	Chr8:113636347-113644100 (+)
CAST/EiJ	MGP_CASTEiJ_G0033240	protein coding gene	Chr8:125098377-125106476 (+)
CBA/J	MGP_CBAJ_G0033886	protein coding gene	Chr8:135007603-135019290 (+)
DBA/2J	MGP_DBA2J_G0034042	protein coding gene	Chr8:119991972-119999876 (+)
FVB/NJ	MGP_FVBNJ_G0033985	protein coding gene	Chr8:119135783-119143537 (+)
LP/J	MGP_LPJ_G0034131	protein coding gene	Chr8:126142420-126150686 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034032	protein coding gene	Chr8:137186883-137194786 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034740	protein coding gene	Chr8:124503099-124511010 (+)
PWK/PhJ	MGP_PWKPhJ_G0032942	protein coding gene	Chr8:119812661-119820896 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032782	protein coding gene	Chr8:123228222-123235553 (+)
WSB/EiJ	MGP_WSBEiJ_G0033356	protein coding gene	Chr8:125259758-125268420 (+)

Human Ortholog

CTU2, cytosolic thiouridylase subunit 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTU2, cytosolic thiouridylase subunit 2
Synonyms

C16orf84, MFRG, NCS2, UPF0432
Links

HGNC:28005

NCBI Gene ID: 348180

neXtProt AC: NX_Q2VPK5

UniProt: Q2VPK5
Chr Location

16q24.3; chr16:88706483-88715396 (+) GRCh38

MGI Vertebrate Homology

Ctu2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CTU2
Gene Tree

Ctu2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

1
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

8
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctu2

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All Sequences

63
RefSeq

8
UniProt

6
CCDS

CCDS52694.1

Ensembl

ENSMUSG00000049482 (Evidence)
NCBI Gene

66965

			Length	Strain/Species	Flank
genomic	66965	NCBI Gene Model \| MGI Sequence Detail	6950	C57BL/6J	± kb
transcript	NM_153775	RefSeq \| MGI Sequence Detail	3066	C57BL/6
polypeptide	Q3U308	UniProt \| EBI \| MGI Sequence Detail	514	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000006039 cytoplasmic tRNA 2-thiolation protein 2

(term hierarchy)
InterPro Domains

IPR019407 Cytoplasmic tRNA 2-thiolation protein 2

IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
GlyGen

Q3U308 1 site, 1 O-linked glycan (1 site)

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All nucleic 9

cDNA 8

Other 1

Microarray probesets 3

Summaries

All 27

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ctu2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79873	Chr8:123202891-123202933 (+)	30 bp
Tssr79874	Chr8:123202935-123202962 (+)	67 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24