Ssbp2 MGI Mouse Gene Detail - MGI:1914220 - single-stranded DNA binding protein 2

Symbol

Ssbp2
Name

single-stranded DNA binding protein 2
Synonyms

1500004K09Rik, 2310079I02Rik, 9330163K02Rik, A830008M03Rik, Hspc116, Ssdp2

Feature Type

protein coding gene
IDs

MGI:1914220
NCBI Gene: 66970
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr13:91608402-91851548 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 47.43 cM
Mapping Data

2 experiments

SNPs within 2kb

6108 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914220	protein coding gene	Chr13:91608402-91854299 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020807	protein coding gene	Chr13:92726430-92997014 (+)
A/J	MGP_AJ_G0020761	protein coding gene	Chr13:89303384-89558742 (+)
AKR/J	MGP_AKRJ_G0020734	protein coding gene	Chr13:92013712-92278390 (+)
BALB/cJ	MGP_BALBcJ_G0020757	protein coding gene	Chr13:89947186-90194835 (+)
C3H/HeJ	MGP_C3HHeJ_G0020551	protein coding gene	Chr13:91704184-91965480 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021194	protein coding gene	Chr13:95591062-95850894 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018762	protein coding gene	Chr13:85277345-85518686 (+)
CAST/EiJ	MGP_CASTEiJ_G0020070	protein coding gene	Chr13:90967878-91230578 (+)
CBA/J	MGP_CBAJ_G0020510	protein coding gene	Chr13:99365870-99648698 (+)
DBA/2J	MGP_DBA2J_G0020635	protein coding gene	Chr13:89074429-89320543 (+)
FVB/NJ	MGP_FVBNJ_G0020615	protein coding gene	Chr13:87892930-88137499 (+)
LP/J	MGP_LPJ_G0020708	protein coding gene	Chr13:92863573-93117131 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020644	protein coding gene	Chr13:99881279-100152080 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021234	protein coding gene	Chr13:91426269-91685379 (+)
PWK/PhJ	MGP_PWKPhJ_G0019822	protein coding gene	Chr13:87816895-88074845 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019646	protein coding gene	Chr13:87692643-87949916 (+)
WSB/EiJ	MGP_WSBEiJ_G0020127	protein coding gene	Chr13:91906530-92164534 (+)

Human Ortholog

SSBP2, single stranded DNA binding protein 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SSBP2, single stranded DNA binding protein 2
Synonyms

HSPC116, SOSS-B2
Links

HGNC:15831

NCBI Gene ID: 23635

neXtProt AC: NX_P81877

UniProt: P81877
Chr Location

5q14.1; chr5:81412804-81751807 (-) GRCh38

MGI Vertebrate Homology

Ssbp2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SSBP2
Gene Tree

Ssbp2

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Phenotype Summary

31 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Gene trapped

1
Targeted

5
Transposon induced

1
Genomic Mutations

1 involving Ssbp2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice exhibit some perinatal lethality and premature death associated with increased incidence of lymphoma and carcinoma.

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1083
Tissues

119
cDNA Data

19
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ssbp2

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All Sequences

122
RefSeq

63
UniProt

5
CCDS

CCDS26676.1, CCDS26677.1

Ensembl

ENSMUSG00000003992 (Evidence)
NCBI Gene

66970

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003992	Ensembl Gene Model \| MGI Sequence Detail	243147	C57BL/6J	± kb
transcript	ENSMUST00000004094	Ensembl \| MGI Sequence Detail	3957	Not Applicable
polypeptide	ENSMUSP00000004094	Ensembl \| MGI Sequence Detail	361	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000015649 single-stranded DNA-binding protein 2

(term hierarchy)
InterPro Domains

IPR006594 LIS1 homology motif

IPR008116 Sequence-specific single-strand DNA-binding protein
GlyGen

Q9CYZ8 1 site, 1 O-linked glycan (1 site)

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All nucleic 23

cDNA 21

Primer pair 1

Other 1

Microarray probesets 6

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MGI:1923746, MGI:2145381, MGI:2145460, MGI:2442615, MGI:2442986

Summaries

All 52

Developmental Gene Expression 7

Gene Ontology 6

Phenotypes 16
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ssbp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120598	Chr13:91609224-91609231 (+)	826 bp
Tssr120599	Chr13:91609233-91609244 (+)	837 bp
Tssr120600	Chr13:91609245-91609262 (+)	852 bp
Tssr120601	Chr13:91609264-91609307 (+)	884 bp
Tssr120602	Chr13:91609318-91609323 (+)	919 bp
Tssr120603	Chr13:91632658-91632675 (+)	24,265 bp
Tssr120604	Chr13:91632679-91632694 (+)	24,285 bp
Tssr120605	Chr13:91644363-91644364 (+)	35,962 bp
Tssr120606	Chr13:91652596-91652608 (+)	44,200 bp
Tssr120607	Chr13:91712439-91712453 (+)	104,044 bp
Tssr120608	Chr13:91729945-91729950 (+)	121,546 bp
Tssr120609	Chr13:91754563-91754569 (+)	146,164 bp
Tssr120610	Chr13:91757396-91757422 (+)	149,007 bp
Tssr120611	Chr13:91772416-91772423 (+)	164,018 bp
Tssr120612	Chr13:91824901-91824912 (+)	216,505 bp
Tssr120613	Chr13:91826735-91826750 (+)	218,341 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24