Lap3 MGI Mouse Gene Detail - MGI:1914238 - leucine aminopeptidase 3

Symbol

Lap3
Name

leucine aminopeptidase 3
Synonyms

LAP, Pep-7, Pep7, Pep-S, peptidase S

Feature Type

protein coding gene
IDs

MGI:1914238
NCBI Gene: 66988
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:45650716-45670033 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 24.98 cM
Mapping Data

11 experiments

SNPs within 2kb

681 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914238	protein coding gene	Chr5:45650716-45670033 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029533	protein coding gene	Chr5:44197181-44218340 (+)
A/J	MGP_AJ_G0029501	protein coding gene	Chr5:42662592-42681954 (+)
AKR/J	MGP_AKRJ_G0029449	protein coding gene	Chr5:44154246-44173605 (+)
BALB/cJ	MGP_BALBcJ_G0029510	protein coding gene	Chr5:43146208-43165491 (+)
C3H/HeJ	MGP_C3HHeJ_G0029233	protein coding gene	Chr5:44159181-44178519 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029964	protein coding gene	Chr5:46289330-46308608 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027203	protein coding gene	Chr5:39832778-39851739 (+)
CAST/EiJ	MGP_CASTEiJ_G0028641	protein coding gene	Chr5:43304053-43323341 (+)
CBA/J	MGP_CBAJ_G0029202	protein coding gene	Chr5:47555718-47579687 (+)
DBA/2J	MGP_DBA2J_G0029348	protein coding gene	Chr5:42749652-42768979 (+)
FVB/NJ	MGP_FVBNJ_G0029308	protein coding gene	Chr5:42178565-42198083 (+)
LP/J	MGP_LPJ_G0029433	protein coding gene	Chr5:44682921-44703827 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029336	protein coding gene	Chr5:48301410-48320740 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029997	protein coding gene	Chr5:43671605-43691961 (+)
PWK/PhJ	MGP_PWKPhJ_G0028365	protein coding gene	Chr5:41875890-41895239 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028199	protein coding gene	Chr5:43115702-43138178 (+)
WSB/EiJ	MGP_WSBEiJ_G0028722	protein coding gene	Chr5:43735612-43754874 (+)

Human Ortholog

LAP3, leucine aminopeptidase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LAP3, leucine aminopeptidase 3
Synonyms

HEL-S-106, LAP, LAPEP, PEPS
Links

HGNC:18449

NCBI Gene ID: 51056

neXtProt AC: NX_P28838

UniProt: P28838
Chr Location

4p15.32; chr4:17577198-17607972 (+) GRCh38

MGI Vertebrate Homology

Lap3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LAP3
Gene Tree

Lap3

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
28 phenotype references

All Mutations and Alleles

21
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

11
Radiation induced

2
Spontaneous

1
Targeted

1
Genomic Mutations

5 involving Lap3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available

Mice homozygous for a knock-out allele are viable and developmentally normal with no detectable abnormalities in generating peptides presented by MHC class I under constitutive conditions or after stimulation with IFN.

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All GO Annotations

10
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

841
Tissues

100
cDNA Data

271
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lap3

ZFIN lap3

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All Sequences

56
RefSeq

2
UniProt

2
CCDS

CCDS19274.1

Ensembl

ENSMUSG00000039682 (Evidence)
NCBI Gene

66988

			Length	Strain/Species	Flank
genomic	66988	NCBI Gene Model \| MGI Sequence Detail	19318	C57BL/6J	± kb
transcript	NM_024434	RefSeq \| MGI Sequence Detail	2267	ZRU/MplStud
polypeptide	Q9CPY7	UniProt \| EBI \| MGI Sequence Detail	519	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009664 cytosol aminopeptidase

(term hierarchy)
EC

3.4.11.1, 3.4.11.5, 3.4.13.23
InterPro Domains

IPR043472 Macro domain-like

IPR023042 Peptidase M17, leucine aminopeptidase

IPR011356 Peptidase M17, leucine aminopeptidase/peptidase B

IPR000819 Peptidase M17, leucyl aminopeptidase, C-terminal

IPR008283 Peptidase M17, leucyl aminopeptidase, N-terminal
GlyGen

Q9CPY7 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 271

cDNA 271

Microarray probesets 3

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MGD-MRK-13235, MGD-MRK-13240, MGI:2140751, MGI:97543

Summaries

All 70

Developmental Gene Expression 4

Diseases 1

Gene Ontology 8

Phenotypes 28
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Lap3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr1476	Chr5:45650716-45650726 (+)	5 bp
Tssr46135	Chr5:45650727-45650779 (+)	37 bp
Tssr46136	Chr5:45650791-45650808 (+)	84 bp
Tssr46137	Chr5:45650823-45650840 (+)	116 bp
Tssr46138	Chr5:45669663-45669679 (+)	18,955 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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