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Lap3 Gene Detail
Summary
  • Symbol
    Lap3
  • Name
    leucine aminopeptidase 3
  • Synonyms
    LAP, Pep-7, Pep7, Pep-S, peptidase S
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914238
    NCBI Gene: 66988
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:45650716-45670033 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 24.98 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    681 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914238
 protein coding gene Chr5:45650716-45670033 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029533
 protein coding gene Chr5:44197181-44218340 (+)
A/J MGP_AJ_G0029501
 protein coding gene Chr5:42662592-42681954 (+)
AKR/J MGP_AKRJ_G0029449
 protein coding gene Chr5:44154246-44173605 (+)
BALB/cJ MGP_BALBcJ_G0029510
 protein coding gene Chr5:43146208-43165491 (+)
C3H/HeJ MGP_C3HHeJ_G0029233
 protein coding gene Chr5:44159181-44178519 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029964
 protein coding gene Chr5:46289330-46308608 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027203
 protein coding gene Chr5:39832778-39851739 (+)
CAST/EiJ MGP_CASTEiJ_G0028641
 protein coding gene Chr5:43304053-43323341 (+)
CBA/J MGP_CBAJ_G0029202
 protein coding gene Chr5:47555718-47579687 (+)
DBA/2J MGP_DBA2J_G0029348
 protein coding gene Chr5:42749652-42768979 (+)
FVB/NJ MGP_FVBNJ_G0029308
 protein coding gene Chr5:42178565-42198083 (+)
LP/J MGP_LPJ_G0029433
 protein coding gene Chr5:44682921-44703827 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029336
 protein coding gene Chr5:48301410-48320740 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029997
 protein coding gene Chr5:43671605-43691961 (+)
PWK/PhJ MGP_PWKPhJ_G0028365
 protein coding gene Chr5:41875890-41895239 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028199
 protein coding gene Chr5:43115702-43138178 (+)
WSB/EiJ MGP_WSBEiJ_G0028722
 protein coding gene Chr5:43735612-43754874 (+)



Homology
more
  • Human Ortholog
    LAP3, leucine aminopeptidase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAP3, leucine aminopeptidase 3
  • Synonyms
    HEL-S-106, LAP, LAPEP, PEPS
  • Links
    NCBI Gene ID: 51056
    neXtProt AC: NX_P28838
    UniProt: P28838

  • Chr Location
    4p15.32; chr4:17577198-17607972 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    28 phenotype references
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    4
  • Gene trapped
    11
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    5 involving Lap3
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    37 strains or lines available
Mice homozygous for a knock-out allele are viable and developmentally normal with no detectable abnormalities in generating peptides presented by MHC class I under constitutive conditions or after stimulation with IFN.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    841
  • Tissues
    100
  • cDNA Data
    271
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66988 NCBI Gene Model | MGI Sequence Detail 19318 C57BL/6J ±  kb
transcript NM_024434 RefSeq | MGI Sequence Detail 2267 ZRU/MplStud  
polypeptide Q9CPY7 UniProt | EBI | MGI Sequence Detail 519 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 271
    cDNA 271

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13235, MGD-MRK-13240, MGI:2140751, MGI:97543
References
more
  • Summaries
    All 70
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 8
    Phenotypes 28
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory