Cep19 MGI Mouse Gene Detail - MGI:1914244

Symbol

Cep19
Name

centrosomal protein 19
Synonyms

1500031L02Rik

Feature Type

protein coding gene
IDs

MGI:1914244
NCBI Gene: 66994
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr16:31918618-31926875 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 22.40 cM
Mapping Data

2 experiments

SNPs within 2kb

288 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914244	protein coding gene	Chr16:31918618-31926887 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022729	protein coding gene	Chr16:30133184-30142456 (+)
A/J	MGP_AJ_G0022694	protein coding gene	Chr16:28729435-28738643 (+)
AKR/J	MGP_AKRJ_G0022667	protein coding gene	Chr16:29774389-29786008 (+)
BALB/cJ	MGP_BALBcJ_G0022696	protein coding gene	Chr16:28882148-28890438 (+)
C3H/HeJ	MGP_C3HHeJ_G0022461	protein coding gene	Chr16:29896960-29910254 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023145	protein coding gene	Chr16:30779147-30787278 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020663	protein coding gene	Chr16:29103489-29111500 (+)
CAST/EiJ	MGP_CASTEiJ_G0021989	protein coding gene	Chr16:30027374-30035816 (+)
CBA/J	MGP_CBAJ_G0022431	protein coding gene	Chr16:32034815-32043000 (+)
DBA/2J	MGP_DBA2J_G0022564	protein coding gene	Chr16:28583229-28591495 (+)
FVB/NJ	MGP_FVBNJ_G0022539	protein coding gene	Chr16:28565506-28573830 (+)
LP/J	MGP_LPJ_G0022631	protein coding gene	Chr16:29913240-29924322 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022558	protein coding gene	Chr16:31486851-31494805 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023157	protein coding gene	Chr16:29752456-29761002 (+)
PWK/PhJ	MGP_PWKPhJ_G0021728	protein coding gene	Chr16:28899696-28908046 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021559	protein coding gene	Chr16:29550616-29559370 (+)
WSB/EiJ	MGP_WSBEiJ_G0022033	protein coding gene	Chr16:29690997-29698908 (+)

Human Ortholog

CEP19, centrosomal protein 19

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CEP19, centrosomal protein 19
Synonyms

C3orf34, MOSPGF
Links

HGNC:28209

NCBI Gene ID: 84984

neXtProt AC: NX_Q96LK0

UniProt: Q96LK0
Chr Location

3q29; chr3:196706277-196712250 (-) GRCh38

MGI Vertebrate Homology

Cep19 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CEP19
Gene Tree

Cep19

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Phenotype Summary

24 phenotypes from 3 alleles in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

3
Gene trapped

2
Targeted

7
Genomic Mutations

1 involving Cep19
Incidental Mutations

APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit obesity, hyperphagia, glucose intolerant and insulin resistant.

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All GO Annotations

24
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

30
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cep19

ZFIN cep19

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All Sequences

40
RefSeq

4
UniProt

1
CCDS

CCDS28114.1

Ensembl

ENSMUSG00000035790 (Evidence)
NCBI Gene

66994

			Length	Strain/Species	Flank
genomic	66994	NCBI Gene Model \| MGI Sequence Detail	8258	C57BL/6J	± kb
transcript	NM_001416014	RefSeq \| MGI Sequence Detail	1738	C57BL/6
polypeptide	Q9CQA8	UniProt \| EBI \| MGI Sequence Detail	163	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031000 centrosomal protein of 19 kDa

(term hierarchy)
InterPro Domains

IPR029412 Centrosomal protein of 19kDa

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All nucleic 30

cDNA 30

Microarray probesets 4

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MGI:2146429, MGI:2146522

Summaries

All 36

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cep19:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137939	Chr16:31918599-31918675 (+)	19 bp
Tssr137940	Chr16:31918722-31918791 (+)	139 bp
Tssr137941	Chr16:31918858-31918873 (+)	248 bp
Tssr137942	Chr16:31921349-31921359 (+)	2,736 bp
Tssr137943	Chr16:31921744-31921756 (+)	3,132 bp
Tssr137944	Chr16:31923904-31923940 (+)	5,304 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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