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Rrp8 Gene Detail
Summary
  • Symbol
    Rrp8
  • Name
    ribosomal RNA processing 8
  • Synonyms
    1500003O22Rik, 2900001K19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914251
    NCBI Gene: 101867
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:105380937-105386592 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 55.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    188 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914251
 protein coding gene Chr7:105380937-105386592 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032761
 protein coding gene Chr7:109001496-109006665 (-)
A/J MGP_AJ_G0032741
 protein coding gene Chr7:106152154-106157323 (-)
AKR/J MGP_AKRJ_G0032674
 protein coding gene Chr7:108918814-108923941 (-)
BALB/cJ MGP_BALBcJ_G0032747
 protein coding gene Chr7:105860676-105865845 (-)
C3H/HeJ MGP_C3HHeJ_G0032456
 protein coding gene Chr7:109024971-109031480 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033252
 protein coding gene Chr7:113361113-113367112 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030236
 protein coding gene Chr7:108119358-108124546 (-)
CAST/EiJ MGP_CASTEiJ_G0031786
 protein coding gene Chr7:100852219-100857384 (-)
CBA/J MGP_CBAJ_G0032430
 protein coding gene Chr7:117134265-117139815 (-)
DBA/2J MGP_DBA2J_G0032583
 protein coding gene Chr7:104412340-104417506 (-)
FVB/NJ MGP_FVBNJ_G0032536
 protein coding gene Chr7:104219471-104225443 (-)
LP/J MGP_LPJ_G0032674
 protein coding gene Chr7:110406217-110412778 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032568
 protein coding gene Chr7:118711847-118717021 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033273
 protein coding gene Chr7:107989634-107994783 (-)
PWK/PhJ MGP_PWKPhJ_G0031499
 protein coding gene Chr7:97353326-97358512 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031348
 protein coding gene Chr7:95099633-95104783 (-)
WSB/EiJ MGP_WSBEiJ_G0031903
 protein coding gene Chr7:108625878-108632130 (-)



Homology
more
  • Human Ortholog
    RRP8, ribosomal RNA processing 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RRP8, ribosomal RNA processing 8
  • Synonyms
    KIAA0409, NML
  • Links
    NCBI Gene ID: 23378
    neXtProt AC: NX_O43159
    UniProt: O43159

  • Chr Location
    11p15.4; chr11:6595072-6603616 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    792
  • Tissues
    68
  • cDNA Data
    70
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 101867 NCBI Gene Model | MGI Sequence Detail 5656 C57BL/6J ±  kb
    transcript NM_133951 RefSeq | MGI Sequence Detail 2890 C57BL/6  
    polypeptide Q9DB85 UniProt | EBI | MGI Sequence Detail 457 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000030747 ribosomal RNA-processing protein 8
      (term hierarchy)
    • EC
      2.1.1.-
    • InterPro Domains
      IPR007823 Ribosomal RNA processing protein 8
      IPR042036 Ribosomal RNA-processing protein 8, N-terminal domain
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
      IPR023576 UbiE/COQ5 methyltransferase, conserved site
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 71

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917639, MGI:2142244
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 23
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory