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Fam210b Gene Detail
Summary
  • Symbol
    Fam210b
  • Name
    family with sequence similarity 210, member B
  • Synonyms
    2010011I20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914267
    NCBI Gene: 67017
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:172187485-172197669 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 94.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    433 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914267
 protein coding gene Chr2:172187444-172197669 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026941
 protein coding gene Chr2:178514750-178526021 (+)
A/J MGP_AJ_G0026908
 protein coding gene Chr2:171039626-171049718 (+)
AKR/J MGP_AKRJ_G0026879
 protein coding gene Chr2:176201106-176211201 (+)
BALB/cJ MGP_BALBcJ_G0026917
 protein coding gene Chr2:171430424-171440474 (+)
C3H/HeJ MGP_C3HHeJ_G0026659
 protein coding gene Chr2:176555314-176566260 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027364
 protein coding gene Chr2:183675628-183685760 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024734
 protein coding gene Chr2:164290010-164299823 (+)
CAST/EiJ MGP_CASTEiJ_G0026117
 protein coding gene Chr2:177217604-177227691 (+)
CBA/J MGP_CBAJ_G0026636
 protein coding gene Chr2:190528119-190541597 (+)
DBA/2J MGP_DBA2J_G0026774
 protein coding gene Chr2:170134813-170145111 (+)
FVB/NJ MGP_FVBNJ_G0026740
 protein coding gene Chr2:168731529-168741579 (+)
LP/J MGP_LPJ_G0026875
 protein coding gene Chr2:178445362-178456735 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026759
 protein coding gene Chr2:193521104-193532493 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027421
 protein coding gene Chr2:176161841-176172399 (+)
PWK/PhJ MGP_PWKPhJ_G0025854
 protein coding gene Chr2:169890324-169900792 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025654
 protein coding gene Chr2:175166145-175176285 (+)
WSB/EiJ MGP_WSBEiJ_G0026190
 protein coding gene Chr2:177137806-177149405 (+)



Homology
more
  • Human Ortholog
    FAM210B, family with sequence similarity 210 member B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAM210B, family with sequence similarity 210 member B
  • Synonyms
    5A3, C20orf108, dJ1167H4.1
  • Links
    NCBI Gene ID: 116151
    neXtProt AC: NX_Q96KR6
    UniProt: Q96KR6

  • Chr Location
    20q13.2; chr20:56358974-56368663 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fam210b mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display a low incidence of increased autoantibody levels, splenomegaly, skin ulcers, and impaired erythocyte differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    41
  • cDNA Data
    70
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027495 Ensembl Gene Model | MGI Sequence Detail 10185 C57BL/6J ±  kb
    transcript ENSMUST00000028995 Ensembl | MGI Sequence Detail 3617 Not Applicable  
    polypeptide ENSMUSP00000028995 Ensembl | MGI Sequence Detail 190 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      cDNA 70
      Primer pair 3
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2138942, MGI:2139253
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:351618 Xu Y, et al., Deletion of the Mitochondrial Membrane Protein Fam210b Is Associated with the Development of Systemic Lupus Erythematosus. Int J Mol Sci. 2024 Jul 1;25(13)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory