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Acad9 Gene Detail
Summary
  • Symbol
    Acad9
  • Name
    acyl-Coenzyme A dehydrogenase family, member 9
  • Synonyms
    2600017P15Rik, C630012L17Rik, NPD002
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914272
    NCBI Gene: 229211
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:36120128-36147002 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 17.41 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    798 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914272
 protein coding gene Chr3:36120128-36147006 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027155
 protein coding gene Chr3:33832233-33859412 (+)
A/J MGP_AJ_G0027115
 protein coding gene Chr3:33201922-33234386 (+)
AKR/J MGP_AKRJ_G0027084
 protein coding gene Chr3:33806340-33834597 (+)
BALB/cJ MGP_BALBcJ_G0027127
 protein coding gene Chr3:32961939-32989522 (+)
C3H/HeJ MGP_C3HHeJ_G0026870
 protein coding gene Chr3:33875127-33903858 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027573
 protein coding gene Chr3:35462946-35495410 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024934
 protein coding gene Chr3:30925667-30949748 (+)
CAST/EiJ MGP_CASTEiJ_G0026323
 protein coding gene Chr3:33717202-33745684 (+)
CBA/J MGP_CBAJ_G0026847
 protein coding gene Chr3:36404592-36438731 (+)
DBA/2J MGP_DBA2J_G0026981
 protein coding gene Chr3:32668300-32695162 (+)
FVB/NJ MGP_FVBNJ_G0026949
 protein coding gene Chr3:32125055-32152729 (+)
LP/J MGP_LPJ_G0027093
 protein coding gene Chr3:34606401-34634628 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026969
 protein coding gene Chr3:38859436-38886704 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027632
 protein coding gene Chr3:33655983-33687828 (+)
PWK/PhJ MGP_PWKPhJ_G0026056
 protein coding gene Chr3:32320903-32347368 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025868
 protein coding gene Chr3:33028912-33058219 (+)
WSB/EiJ MGP_WSBEiJ_G0026397
 protein coding gene Chr3:33680145-33706997 (+)



Homology
more
  • Human Ortholog
    ACAD9, acyl-CoA dehydrogenase family member 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACAD9, acyl-CoA dehydrogenase family member 9
  • Synonyms
    MC1DN20, NPD002
  • Links
    NCBI Gene ID: 28976
    neXtProt AC: NX_Q9H845
    UniProt: Q9H845

  • Chr Location
    3q21.3; chr3:128879596-128924003 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Acad9 mouse models; 1 with human ACAD9 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit perinatal lethality. Conditional deletion in cardiac or muscle tissue leads to various phenotypes observed in nuclear type mitochondrial complex I deficiency 20.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    805
  • Tissues
    98
  • cDNA Data
    122
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027710 Ensembl Gene Model | MGI Sequence Detail 26875 C57BL/6J ±  kb
    transcript ENSMUST00000011492 Ensembl | MGI Sequence Detail 3930 Not Applicable  
    polypeptide ENSMUSP00000011492 Ensembl | MGI Sequence Detail 625 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000003599 complex I assembly factor ACAD9, mitochondrial
      (term hierarchy)
    • EC
      1.3.8.-
    • InterPro Domains
      IPR049448 ACAD9/ACADV-like, C-terminal domain
      IPR006089 Acyl-CoA dehydrogenase, conserved site
      IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
      IPR009075 Acyl-CoA dehydrogenase/oxidase, C-terminal
      IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
      IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
      IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
      IPR006091 Acyl-CoA oxidase/dehydrogenase, middle domain
      IPR046373 Acyl-CoA oxidase/dehydrogenase, middle domain superfamily
    • GlyGen
      Q8JZN5 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 125
      cDNA 122
      Primer pair 2
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2444674
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326969 Sinsheimer A, et al., Development and characterization of a mouse model for Acad9 deficiency. Mol Genet Metab. 2021 Sep-Oct;134(1-2):156-163
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory