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Ddx17 Gene Detail
Summary
  • Symbol
    Ddx17
  • Name
    DEAD box helicase 17
  • Synonyms
    2610007K22Rik, A430025E01Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 17, LOC381024, p72
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914290
    NCBI Gene: 67040
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79411937-79430942 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.77 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    391 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914290
 protein coding gene Chr15:79411897-79430976 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022077
 protein coding gene Chr15:79805396-79824286 (-)
A/J MGP_AJ_G0022038
 protein coding gene Chr15:77051747-77070705 (-)
AKR/J MGP_AKRJ_G0022013
 protein coding gene Chr15:79199336-79218904 (-)
BALB/cJ MGP_BALBcJ_G0022044
 protein coding gene Chr15:77052345-77071298 (-)
C3H/HeJ MGP_C3HHeJ_G0021815
 protein coding gene Chr15:79193595-79212566 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022487
 protein coding gene Chr15:82950750-82971128 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020017
 protein coding gene Chr15:73529389-73549504 (-)
CAST/EiJ MGP_CASTEiJ_G0021336
 protein coding gene Chr15:79905092-79924096 (-)
CBA/J MGP_CBAJ_G0021780
 protein coding gene Chr15:85534650-85555283 (-)
DBA/2J MGP_DBA2J_G0021909
 protein coding gene Chr15:76538586-76557540 (-)
FVB/NJ MGP_FVBNJ_G0021887
 protein coding gene Chr15:75564099-75583280 (-)
LP/J MGP_LPJ_G0021977
 protein coding gene Chr15:79995218-80016080 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021907
 protein coding gene Chr15:90633439-90653257 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022501
 protein coding gene Chr15:79218725-79238182 (-)
PWK/PhJ MGP_PWKPhJ_G0021078
 protein coding gene Chr15:76548862-76568060 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020915
 protein coding gene Chr15:79036482-79055700 (-)
WSB/EiJ MGP_WSBEiJ_G0021388
 protein coding gene Chr15:79599577-79620861 (-)



Homology
more
  • Human Ortholog
    DDX17, DEAD-box helicase 17
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX17, DEAD-box helicase 17
  • Synonyms
    P72, RH70
  • Links
    NCBI Gene ID: 10521
    neXtProt AC: NX_Q92841
    UniProt: Q92841

  • Chr Location
    22q13.1; chr22:38483438-38507660 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    941
  • Tissues
    45
  • cDNA Data
    641
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055065 Ensembl Gene Model | MGI Sequence Detail 19006 C57BL/6J ±  kb
transcript ENSMUST00000054014 Ensembl | MGI Sequence Detail 4732 Not Applicable  
polypeptide ENSMUSP00000055535 Ensembl | MGI Sequence Detail 652 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000029383 probable ATP-dependent RNA helicase DDX17
    (term hierarchy)
  • EC
    3.6.4.13
  • InterPro Domains
    IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
    IPR046330 DEAD box protein 17, ATP-binding domain
    IPR011545 DEAD/DEAH box helicase domain
    IPR001650 Helicase, C-terminal domain-like
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
  • GlyGen
    Q501J6 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 643
    cDNA 642
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2145942, MGI:2146298, MGI:2685772
References
more
  • Summaries
    All 80
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 13
    Phenotypes 34
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:349803 Yan M, et al., DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure. Signal Transduct Target Ther. 2024 May 24;9(1):127
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory