Ift27 MGI Mouse Gene Detail - MGI:1914292 - intraflagellar transport 27

Symbol

Ift27
Name

intraflagellar transport 27
Synonyms

2600013G09Rik, Rabl4

Feature Type

protein coding gene
IDs

MGI:1914292
NCBI Gene: 67042
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr15:78043660-78058281 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 36.92 cM, cytoband E2
Mapping Data

3 experiments

SNPs within 2kb

516 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914292	protein coding gene	Chr15:78043660-78058307 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022036	protein coding gene	Chr15:78321843-78336462 (-)
A/J	MGP_AJ_G0021996	protein coding gene	Chr15:75592223-75606854 (-)
AKR/J	MGP_AKRJ_G0021973	protein coding gene	Chr15:77668871-77683341 (-)
BALB/cJ	MGP_BALBcJ_G0022004	protein coding gene	Chr15:75607802-75622433 (-)
C3H/HeJ	MGP_C3HHeJ_G0021775	protein coding gene	Chr15:77746465-77761097 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022446	protein coding gene	Chr15:81395098-81409595 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019975	protein coding gene	Chr15:72157025-72172247 (-)
CAST/EiJ	MGP_CASTEiJ_G0021295	protein coding gene	Chr15:78357393-78373575 (-)
CBA/J	MGP_CBAJ_G0021740	protein coding gene	Chr15:83905189-83919806 (-)
DBA/2J	MGP_DBA2J_G0021868	protein coding gene	Chr15:75088792-75103412 (-)
FVB/NJ	MGP_FVBNJ_G0021847	protein coding gene	Chr15:74081542-74096161 (-)
LP/J	MGP_LPJ_G0021937	protein coding gene	Chr15:78491564-78506195 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021867	protein coding gene	Chr15:89096673-89116825 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022460	protein coding gene	Chr15:77775132-77789818 (-)
PWK/PhJ	MGP_PWKPhJ_G0021037	protein coding gene	Chr15:75072759-75087554 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020873	protein coding gene	Chr15:77536598-77551222 (-)
WSB/EiJ	MGP_WSBEiJ_G0021348	protein coding gene	Chr15:78093612-78108246 (-)

Human Ortholog

IFT27, intraflagellar transport 27

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IFT27, intraflagellar transport 27
Synonyms

BBS19, CFAP156, FAP156, RABL4, RAYL
Links

HGNC:18626

NCBI Gene ID: 11020

neXtProt AC: NX_Q9BW83

UniProt: Q9BW83
Chr Location

22q12.3; chr22:36758202-36776256 (-) GRCh38

MGI Vertebrate Homology

Ift27 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IFT27
Gene Tree

Ift27

Diseases

1 with human IFT27 associations

				Human Disease	Mouse Models
				Bardet-Biedl syndrome 19 IDs Bardet-Biedl syndrome 19 DOID:0110141 ICD10CM:Q87.89 OMIM:615996

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

66 phenotypes from 3 alleles in 3 genetic backgrounds
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Radiation induced

2
Targeted

9
Genomic Mutations

3 involving Ift27
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice die shortly after birth showing multiple structural birth defects, including heart, lung, skeletal, and brain abnormalities, associated with abnormal Hedgehog signaling. Hair follicle development is severely impaired but formation of the ciliary axoneme is normal.

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All GO Annotations

38
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

741
Tissues

12
cDNA Data

61
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ift27

ZFIN ift27

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All Sequences

40
RefSeq

2
UniProt

3
CCDS

CCDS37131.1

Ensembl

ENSMUSG00000016637 (Evidence)
NCBI Gene

67042

			Length	Strain/Species	Flank
genomic	67042	NCBI Gene Model \| MGI Sequence Detail	14622	C57BL/6J	± kb
transcript	NM_025931	RefSeq \| MGI Sequence Detail	1003	Not Specified
polypeptide	Q9D0P8	UniProt \| EBI \| MGI Sequence Detail	186	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029557 intraflagellar transport protein 27 homolog

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR050209 Rab GTPases family involved in membrane trafficking

IPR001806 Small GTPase

IPR005225 Small GTP-binding protein domain

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All nucleic 64

cDNA 61

Primer pair 2

Other 1

Microarray probesets 4

Summaries

All 66

Developmental Gene Expression 4

Diseases 1

Gene Ontology 16

Phenotypes 30
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:307611 Huang Q, et al., Leucine zipper transcription factor-like 1 (LZTFL1), an intraflagellar transporter protein 27 (IFT27) associated protein, is required for normal sperm function and male fertility. Dev Biol. 2021 Sep;477:164-176

TSS for Ift27:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135176	Chr15:78058290-78058309 (-)	-19 bp
Tssr135175	Chr15:78058226-78058289 (-)	23 bp
Tssr135174	Chr15:78058156-78058188 (-)	109 bp
Tssr135173	Chr15:78058126-78058147 (-)	144 bp
Tssr135172	Chr15:78058027-78058040 (-)	247 bp
Tssr135171	Chr15:78056615-78056659 (-)	1,644 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24