Tbc1d7 MGI Mouse Gene Detail - MGI:1914296 - TBC1 domain family, member 7

Symbol

Tbc1d7
Name

TBC1 domain family, member 7
Synonyms

2610009C09Rik

Feature Type

protein coding gene
IDs

MGI:1914296
NCBI Gene: 67046
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr13:43305216-43324977 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 21.31 cM, cytoband A5
Mapping Data

2 experiments

SNPs within 2kb

756 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914296	protein coding gene	Chr13:43305214-43324977 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020496	protein coding gene	Chr13:41733840-41754318 (-)
A/J	MGP_AJ_G0020450	protein coding gene	Chr13:40327826-40347519 (-)
AKR/J	MGP_AKRJ_G0020428	protein coding gene	Chr13:41439820-41459577 (-)
BALB/cJ	MGP_BALBcJ_G0020446	protein coding gene	Chr13:40535558-40558391 (-)
C3H/HeJ	MGP_C3HHeJ_G0020245	protein coding gene	Chr13:41300024-41327925 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020879	protein coding gene	Chr13:43031686-43053614 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018466	protein coding gene	Chr13:38425121-38444916 (-)
CAST/EiJ	MGP_CASTEiJ_G0019760	protein coding gene	Chr13:41136554-41158206 (-)
CBA/J	MGP_CBAJ_G0020206	protein coding gene	Chr13:44863073-44884016 (-)
DBA/2J	MGP_DBA2J_G0020328	protein coding gene	Chr13:39890639-39910185 (-)
FVB/NJ	MGP_FVBNJ_G0020307	protein coding gene	Chr13:39398933-39426808 (-)
LP/J	MGP_LPJ_G0020403	protein coding gene	Chr13:41980993-42001713 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020336	protein coding gene	Chr13:44768560-44788872 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020922	protein coding gene	Chr13:41100098-41120371 (-)
PWK/PhJ	MGP_PWKPhJ_G0019515	protein coding gene	Chr13:40001559-40021792 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019345	protein coding gene	Chr13:39733713-39753222 (-)
WSB/EiJ	MGP_WSBEiJ_G0019822	protein coding gene	Chr13:41409788-41437084 (-)

Human Ortholog

TBC1D7, TBC1 domain family member 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TBC1D7, TBC1 domain family member 7
Synonyms

MGCPH, PIG51, TBC7
Links

HGNC:21066

NCBI Gene ID: 51256

neXtProt AC: NX_Q9P0N9

UniProt: Q9P0N9
Chr Location

6p24.1; chr6:13266542-13328583 (-) GRCh38

MGI Vertebrate Homology

Tbc1d7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TBC1D7
Gene Tree

Tbc1d7

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Targeted

2
Genomic Mutations

1 involving Tbc1d7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced neuron specification, increased brain weight, reduced gripe strength, hypoactivity, abnormal gait, and increased lean body mass.

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All GO Annotations

33
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

744
Tissues

6
cDNA Data

9
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tbc1d7

ZFIN tbc1d7

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All Sequences

67
RefSeq

10
UniProt

7
CCDS

CCDS26476.1, CCDS88446.1

Ensembl

ENSMUSG00000021368 (Evidence)
NCBI Gene

67046

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021368	Ensembl Gene Model \| MGI Sequence Detail	19762	C57BL/6J	± kb
transcript	ENSMUST00000021797	Ensembl \| MGI Sequence Detail	1239	Not Applicable
polypeptide	ENSMUSP00000021797	Ensembl \| MGI Sequence Detail	293	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000016120 TBC1 domain family member 7

(term hierarchy)
InterPro Domains

IPR000195 Rab-GAP-TBC domain

IPR035969 Rab-GAP-TBC domain superfamily

IPR039842 TBC1 domain family member 7

IPR043039 TBC1 domain family member 7, domain 2

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All nucleic 9

cDNA 9

Microarray probesets 3

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 10
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:325096 Schrotter S, et al., The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth. Cell Rep. 2022 May 17;39(7):110824

TSS for Tbc1d7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122245	Chr13:43324937-43324964 (-)	26 bp
Tssr122244	Chr13:43324913-43324933 (-)	54 bp
Tssr122243	Chr13:43324851-43324900 (-)	101 bp
Tssr122242	Chr13:43324827-43324844 (-)	141 bp
Tssr122241	Chr13:43313037-43313045 (-)	11,936 bp
Tssr122240	Chr13:43308288-43308297 (-)	16,684 bp
Tssr122239	Chr13:43308268-43308281 (-)	16,702 bp
Tssr122238	Chr13:43308253-43308266 (-)	16,717 bp
Tssr122237	Chr13:43308225-43308242 (-)	16,743 bp
Tssr122236	Chr13:43308215-43308220 (-)	16,759 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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