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Paics Gene Detail
Summary
  • Symbol
    Paics
  • Name
    phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
  • Synonyms
    2610511I09Rik, ADE2H1, AIRC, PAIS
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914304
    NCBI Gene: 67054
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:77099154-77115356 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 41.45 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    521 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914304
 protein coding gene Chr5:77099149-77115356 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029650
 protein coding gene Chr5:77165024-77181453 (+)
A/J MGP_AJ_G0029618
 protein coding gene Chr5:74214751-74230958 (+)
AKR/J MGP_AKRJ_G0029566
 protein coding gene Chr5:76636262-76653770 (+)
BALB/cJ MGP_BALBcJ_G0029627
 protein coding gene Chr5:74948873-74965650 (+)
C3H/HeJ MGP_C3HHeJ_G0029350
 protein coding gene Chr5:77010167-77026301 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030081
 protein coding gene Chr5:80248333-80265321 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027322
 protein coding gene Chr5:69845979-69861896 (+)
CAST/EiJ MGP_CASTEiJ_G0028758
 protein coding gene Chr5:76210459-76230698 (+)
CBA/J MGP_CBAJ_G0029319
 protein coding gene Chr5:82889514-82908046 (+)
DBA/2J MGP_DBA2J_G0029464
 protein coding gene Chr5:74271992-74291839 (+)
FVB/NJ MGP_FVBNJ_G0029425
 protein coding gene Chr5:73472872-73489492 (+)
LP/J MGP_LPJ_G0029551
 protein coding gene Chr5:77602394-77618587 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029453
 protein coding gene Chr5:86029938-86048132 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030114
 protein coding gene Chr5:76182286-76199146 (+)
PWK/PhJ MGP_PWKPhJ_G0028481
 protein coding gene Chr5:73290943-73307502 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028316
 protein coding gene Chr5:75539574-75556424 (+)
WSB/EiJ MGP_WSBEiJ_G0028838
 protein coding gene Chr5:76513251-76530832 (+)



Homology
more
  • Human Ortholog
    PAICS, phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAICS, phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  • Synonyms
    ADE2, ADE2H1, AIRC, PAICSD, PAIS
  • Links
    NCBI Gene ID: 10606
    neXtProt AC: NX_P22234
    UniProt: P22234

  • Chr Location
    4q12; chr4:56410507-56464578 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PAICS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    60
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Gene trapped
    56
  • Spontaneous
    1
  • Genomic Mutations
    3 involving Paics
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    35 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    924
  • Tissues
    136
  • cDNA Data
    13
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029247 Ensembl Gene Model | MGI Sequence Detail 16203 C57BL/6J ±  kb
transcript ENSMUST00000031160 Ensembl | MGI Sequence Detail 2482 Not Applicable  
polypeptide ENSMUSP00000031160 Ensembl | MGI Sequence Detail 425 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 45
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory