Trak1 MGI Mouse Gene Detail - MGI:1914345 - trafficking protein, kinesin binding 1

Symbol

Trak1
Name

trafficking protein, kinesin binding 1
Synonyms

2310001H13Rik, hyrt, nm1952

Feature Type

protein coding gene
IDs

MGI:1914345
NCBI Gene: 67095
Alliance

gene page
Transcription Start Sites

21 TSS

Sequence Map

Chr9:121126568-121303984 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 72.41 cM
Mapping Data

3 experiments

SNPs within 2kb

5021 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914345	protein coding gene	Chr9:121126568-121303985 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035441	protein coding gene	Chr9:124306305-124411063 (+)
A/J	MGP_AJ_G0035422	protein coding gene	Chr9:119568536-119675585 (+)
AKR/J	MGP_AKRJ_G0035355	protein coding gene	Chr9:122742311-122854425 (+)
BALB/cJ	MGP_BALBcJ_G0035418	protein coding gene	Chr9:119479033-119584380 (+)
C3H/HeJ	MGP_C3HHeJ_G0035125	protein coding gene	Chr9:123204621-123318157 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035941	protein coding gene	Chr9:127697084-127815234 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032823	protein coding gene	Chr9:116721709-116836300 (+)
CAST/EiJ	MGP_CASTEiJ_G0034430	protein coding gene	Chr9:123247018-123354466 (+)
CBA/J	MGP_CBAJ_G0035093	protein coding gene	Chr9:132372926-132496514 (+)
DBA/2J	MGP_DBA2J_G0035252	protein coding gene	Chr9:119009741-119114392 (+)
FVB/NJ	MGP_FVBNJ_G0035199	protein coding gene	Chr9:117930947-118035974 (+)
LP/J	MGP_LPJ_G0035331	protein coding gene	Chr9:124633762-124748207 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035240	protein coding gene	Chr9:133337628-133453261 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035960	protein coding gene	Chr9:123192736-123304143 (+)
PWK/PhJ	MGP_PWKPhJ_G0034134	protein coding gene	Chr9:119406866-119613757 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033970	protein coding gene	Chr9:123221493-123415416 (+)
WSB/EiJ	MGP_WSBEiJ_G0034550	protein coding gene	Chr9:123040795-123148211 (+)

Human Ortholog

TRAK1, trafficking kinesin protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRAK1, trafficking kinesin protein 1
Synonyms

DEE68, EIEE68, MILT1, OIP106
Links

HGNC:29947

NCBI Gene ID: 22906

neXtProt AC: NX_Q9UPV9

UniProt: Q9UPV9
Chr Location

3p22.1; chr3:42013093-42225890 (+) GRCh38

MGI Vertebrate Homology

Trak1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TRAK1
Gene Tree

Trak1

Diseases

1 with Trak1 mouse models; 1 with human TRAK1 associations

Human Disease

Mouse Models

Stiff-Person syndrome

IDs

View 1 model

developmental and epileptic encephalopathy 68

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

17 phenotypes from 2 alleles in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

5
Gene trapped

4
Spontaneous

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

72 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice with a spontaneous mutation in this allele have various behavioral abnormalities consistent with hypertonia. Inclusions can be found in neuronal processes of the gray matter of the brainstem and spinal cord.

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All GO Annotations

29
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

820
Tissues

31
cDNA Data

17
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trak1

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All Sequences

98
RefSeq

13
UniProt

15
CCDS

CCDS40810.1, CCDS90684.1, CCDS90685.1

Ensembl

ENSMUSG00000032536 (Evidence)
NCBI Gene

67095

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032536	Ensembl Gene Model \| MGI Sequence Detail	177417	C57BL/6J	± kb
transcript	ENSMUST00000238988	Ensembl \| MGI Sequence Detail	3353	Not Applicable
polypeptide	ENSMUSP00000158925	Ensembl \| MGI Sequence Detail	968	Not Applicable

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UniProt

15 Sequences
Protein Ontology

PR:000016607 trafficking kinesin-binding protein 1

(term hierarchy)
InterPro Domains

IPR006933 HAP1, N-terminal

IPR051946 Intracellular Trafficking Regulator

IPR022154 Trafficking kinesin-binding protein, C-terminal
GlyGen

Q6PD31 7 sites, 1 O-linked glycan (5 sites)

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All nucleic 17

cDNA 17

Microarray probesets 6

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MGI:2143032, MGI:2143074, MGI:3044766

Summaries

All 41

Developmental Gene Expression 3

Diseases 1

Gene Ontology 6

Phenotypes 12
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Trak1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87767	Chr9:121126562-121126618 (+)	22 bp
Tssr87768	Chr9:121126627-121126640 (+)	66 bp
Tssr87769	Chr9:121127812-121127823 (+)	1,250 bp
Tssr87770	Chr9:121127842-121127866 (+)	1,286 bp
Tssr87771	Chr9:121129775-121129780 (+)	3,210 bp
Tssr87772	Chr9:121143317-121143334 (+)	16,758 bp
Tssr87773	Chr9:121143346-121143383 (+)	16,797 bp
Tssr87774	Chr9:121143453-121143459 (+)	16,888 bp
Tssr87775	Chr9:121179973-121179975 (+)	53,406 bp
Tssr87776	Chr9:121196086-121196108 (+)	69,529 bp
Tssr87777	Chr9:121209724-121209744 (+)	83,166 bp
Tssr87778	Chr9:121211855-121211873 (+)	85,296 bp
Tssr87779	Chr9:121211925-121211959 (+)	85,374 bp
Tssr87780	Chr9:121232480-121232594 (+)	105,969 bp
Tssr87781	Chr9:121245018-121245027 (+)	118,455 bp
Tssr87782	Chr9:121245035-121245051 (+)	118,475 bp
Tssr87783	Chr9:121281898-121281929 (+)	155,346 bp
Tssr87784	Chr9:121289296-121289305 (+)	162,733 bp
Tssr87785	Chr9:121289318-121289338 (+)	162,760 bp
Tssr87786	Chr9:121289346-121289371 (+)	162,791 bp
Tssr87787	Chr9:121301527-121301531 (+)	174,961 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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