Nrarp MGI Mouse Gene Detail - MGI:1914372 - Notch-regulated ankyrin repeat protein

Symbol

Nrarp
Name

Notch-regulated ankyrin repeat protein
Synonyms

2700054M22Rik

Feature Type

protein coding gene
IDs

MGI:1914372
NCBI Gene: 67122
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr2:25070770-25073351 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 17.05 cM
Mapping Data

1 experiment

SNPs within 2kb

99 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914372	protein coding gene	Chr2:25070770-25073351 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025421	protein coding gene	Chr2:23039771-23042352 (+)
A/J	MGP_AJ_G0025398	protein coding gene	Chr2:22145633-22148214 (+)
AKR/J	MGP_AKRJ_G0025368	protein coding gene	Chr2:22899640-22902221 (+)
BALB/cJ	MGP_BALBcJ_G0025394	protein coding gene	Chr2:22267949-22270530 (+)
C3H/HeJ	MGP_C3HHeJ_G0025155	protein coding gene	Chr2:22829313-22831894 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025838	protein coding gene	Chr2:23776322-23778903 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023249	protein coding gene	Chr2:21076801-21079380 (+)
CAST/EiJ	MGP_CASTEiJ_G0024618	protein coding gene	Chr2:22713125-22715706 (+)
CBA/J	MGP_CBAJ_G0025133	protein coding gene	Chr2:24613863-24616444 (+)
DBA/2J	MGP_DBA2J_G0025266	protein coding gene	Chr2:22001912-22004493 (+)
FVB/NJ	MGP_FVBNJ_G0025228	protein coding gene	Chr2:21740690-21743271 (+)
LP/J	MGP_LPJ_G0025352	protein coding gene	Chr2:22991033-22993614 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025259	protein coding gene	Chr2:24818411-24820992 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025897	protein coding gene	Chr2:22846379-22848960 (+)
PWK/PhJ	MGP_PWKPhJ_G0024366	protein coding gene	Chr2:21812881-21815461 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024166	protein coding gene	Chr2:22994577-22997156 (+)
WSB/EiJ	MGP_WSBEiJ_G0024687	protein coding gene	Chr2:22916650-22919231 (+)

Human Ortholog

NRARP, NOTCH regulated ankyrin repeat protein

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NRARP, NOTCH regulated ankyrin repeat protein
Links

HGNC:33843

NCBI Gene ID: 441478

neXtProt AC: NX_Q7Z6K4

UniProt: Q7Z6K4
Chr Location

9q34.3; chr9:137299631-137302271 (-) GRCh38

MGI Vertebrate Homology

Nrarp stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NRARP
Gene Tree

Nrarp

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Phenotype Summary

25 phenotypes from 3 alleles in 6 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit delayed retinal vascularization due to increased vascular regression. Mice homozygous for a different knock-out allele exhibit vertebral and rib fusions.

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All GO Annotations

34
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1026
Tissues

94
cDNA Data

50
Literature Summary

32

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NRARP

Xenbase nrarp

ZFIN nrarpa, nrarpb

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All Sequences

34
RefSeq

2
UniProt

1
CCDS

CCDS38066.1

Ensembl

ENSMUSG00000078202 (Evidence)
NCBI Gene

67122

			Length	Strain/Species	Flank
genomic	67122	NCBI Gene Model \| MGI Sequence Detail	2582	C57BL/6J	± kb
transcript	NM_025980	RefSeq \| MGI Sequence Detail	2590	AKR/J
polypeptide	Q91ZA8	UniProt \| EBI \| MGI Sequence Detail	114	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011415 notch-regulated ankyrin repeat-containing protein

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

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All nucleic 58

cDNA 51

Primer pair 2

Other 5

Microarray probesets 5

Summaries

All 60

Developmental Gene Expression 32

Gene Ontology 8

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:348800 Clark JF, et al., Diverse Fgfr1 signaling pathways and endocytic trafficking regulate mesoderm development. Genes Dev. 2024 Jun 4;

TSS for Nrarp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16660	Chr2:25070749-25070776 (+)	-7 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24