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Mis12 Gene Detail
Summary
  • Symbol
    Mis12
  • Name
    MIS12 kinetochore complex component
  • Synonyms
    2510025F08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914389
    NCBI Gene: 67139
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70910437-70918197 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 43.21 cM, cytoband B4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    106 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914389
 protein coding gene Chr11:70910394-70918197 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018623
 protein coding gene Chr11:71597918-71605676 (+)
A/J MGP_AJ_G0018591
 protein coding gene Chr11:68876434-68884194 (+)
AKR/J MGP_AKRJ_G0018560
 protein coding gene Chr11:70951430-70960875 (+)
BALB/cJ MGP_BALBcJ_G0018563
 protein coding gene Chr11:69185838-69193596 (+)
C3H/HeJ MGP_C3HHeJ_G0018376
 protein coding gene Chr11:70988267-70996025 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019014
 protein coding gene Chr11:73764799-73772559 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016659
 protein coding gene Chr11:65780971-65788934 (+)
CAST/EiJ MGP_CASTEiJ_G0017931
 protein coding gene Chr11:71257966-71265745 (+)
CBA/J MGP_CBAJ_G0018348
 protein coding gene Chr11:77089759-77097517 (+)
DBA/2J MGP_DBA2J_G0018458
 protein coding gene Chr11:68455384-68463116 (+)
FVB/NJ MGP_FVBNJ_G0018448
 protein coding gene Chr11:68098986-68106744 (+)
LP/J MGP_LPJ_G0018528
 protein coding gene Chr11:72182374-72190132 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018471
 protein coding gene Chr11:77626574-77634334 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019056
 protein coding gene Chr11:71209815-71217573 (+)
PWK/PhJ MGP_PWKPhJ_G0017705
 protein coding gene Chr11:69110810-69142784 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017495
 protein coding gene Chr11:71021890-71028317 (+)
WSB/EiJ MGP_WSBEiJ_G0017985
 protein coding gene Chr11:70873664-70881427 (+)



Homology
more
  • Human Ortholog
    MIS12, MIS12 kinetochore complex component
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIS12, MIS12 kinetochore complex component
  • Synonyms
    2510025F08Rik, hMis12, KNTC2AP, MTW1
  • Links
    NCBI Gene ID: 79003
    neXtProt AC: NX_Q9H081
    UniProt: Q9H081

  • Chr Location
    17p13.2; chr17:5486285-5490814 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotype references
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    8
  • Targeted
    3
  • Genomic Mutations
    2 involving Mis12
  • Find Mice (IMSR)
    13 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    11
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040599 Ensembl Gene Model | MGI Sequence Detail 7761 C57BL/6J ±  kb
transcript ENSMUST00000048807 Ensembl | MGI Sequence Detail 3003 Not Applicable  
polypeptide ENSMUSP00000039500 Ensembl | MGI Sequence Detail 206 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144440
References
more
  • Summaries
    All 45
    Gene Ontology 7
    Phenotypes 16
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory