Arl8b MGI Mouse Gene Detail - MGI:1914416 - ADP-ribosylation factor-like 8B

Symbol

Arl8b
Name

ADP-ribosylation factor-like 8B
Synonyms

2610313E07Rik, 3100002J04Rik, Arl10c

Feature Type

protein coding gene
IDs

MGI:1914416
NCBI Gene: 67166
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr6:108760020-108800684 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 49.87 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

1306 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914416	protein coding gene	Chr6:108760020-108802239 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031102	protein coding gene	Chr6:111070655-111113741 (+)
A/J	MGP_AJ_G0031071	protein coding gene	Chr6:106862564-106908643 (+)
AKR/J	MGP_AKRJ_G0031002	protein coding gene	Chr6:109743691-109787957 (+)
BALB/cJ	MGP_BALBcJ_G0031082	protein coding gene	Chr6:106790585-106833051 (+)
C3H/HeJ	MGP_C3HHeJ_G0030626	protein coding gene	Chr6:74571608-74613079 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031541	protein coding gene	Chr6:113987198-114029388 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028705	protein coding gene	Chr6:104148110-104191593 (+)
CAST/EiJ	MGP_CASTEiJ_G0030189	protein coding gene	Chr6:110124112-110172985 (+)
CBA/J	MGP_CBAJ_G0030768	protein coding gene	Chr6:118387383-118432117 (+)
DBA/2J	MGP_DBA2J_G0030921	protein coding gene	Chr6:105995385-106041800 (+)
FVB/NJ	MGP_FVBNJ_G0030875	protein coding gene	Chr6:105029457-105069934 (+)
LP/J	MGP_LPJ_G0031001	protein coding gene	Chr6:111127362-111170860 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030909	protein coding gene	Chr6:122590759-122634136 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031568	protein coding gene	Chr6:109691181-109735068 (+)
PWK/PhJ	MGP_PWKPhJ_G0029905	protein coding gene	Chr6:104934652-104975216 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029733	protein coding gene	Chr6:108474692-108515000 (+)
WSB/EiJ	MGP_WSBEiJ_G0030273	protein coding gene	Chr6:110220333-110264323 (+)

Human Ortholog

ARL8B, ARF like GTPase 8B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARL8B, ARF like GTPase 8B
Synonyms

ARL10C, Gie1
Links

HGNC:25564

NCBI Gene ID: 55207

neXtProt AC: NX_Q9NVJ2

UniProt: Q9NVJ2
Chr Location

3p26.1; chr3:5122249-5180911 (+) GRCh38

MGI Vertebrate Homology

Arl8b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ARL8B
Gene Tree

Arl8b

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Phenotype Summary

12 phenotypes from 3 alleles in 3 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

1
Gene trapped

8
Spontaneous

1
Targeted

4
Genomic Mutations

1 involving Arl8b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display perinatal lethality with impaired visceral yolk sac function and reduced embryo size.

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All GO Annotations

64
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

944
Tissues

38
cDNA Data

24
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arl8b

ZFIN arl8ba

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All Sequences

69
RefSeq

2
UniProt

3
CCDS

CCDS39586.1

Ensembl

ENSMUSG00000030105 (Evidence)
NCBI Gene

67166

			Length	Strain/Species	Flank
genomic	67166	NCBI Gene Model \| MGI Sequence Detail	40665	C57BL/6J	± kb
transcript	NM_026011	RefSeq \| MGI Sequence Detail	2928	C57BL/6
polypeptide	Q9CQW2	UniProt \| EBI \| MGI Sequence Detail	186	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004296 ADP-ribosylation factor-like protein 8B

(term hierarchy)
EC

3.6.5.2
InterPro Domains

IPR044154 ADP-ribosylation factor-like protein 8A/8B

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR006689 Small GTPase superfamily, ARF/SAR type

IPR005225 Small GTP-binding protein domain
GlyGen

Q9CQW2 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 25

cDNA 24

Primer pair 1

Microarray probesets 8

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MGI:1916525

Summaries

All 52

Developmental Gene Expression 3

Gene Ontology 12

Phenotypes 20
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Arl8b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58089	Chr6:108760025-108760077 (+)	31 bp
Tssr58090	Chr6:108760078-108760096 (+)	67 bp
Tssr58091	Chr6:108760168-108760206 (+)	167 bp
Tssr58092	Chr6:108760210-108760223 (+)	197 bp
Tssr58095	Chr6:108791946-108791967 (+)	31,937 bp
Tssr58096	Chr6:108798532-108798571 (+)	38,532 bp
Tssr58097	Chr6:108798574-108798604 (+)	38,569 bp
Tssr58098	Chr6:108799297-108799301 (+)	39,279 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24