Lpar6 MGI Mouse Gene Detail - MGI:1914418 - lysophosphatidic acid receptor 6

Symbol

Lpar6
Name

lysophosphatidic acid receptor 6
Synonyms

2610302I02Rik, P2ry5, P2y5

Feature Type

protein coding gene
IDs

MGI:1914418
NCBI Gene: 67168
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:73475331-73477798 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 38.75 cM
Mapping Data

1 experiment

SNPs within 2kb

184 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914418	protein coding gene	Chr14:73475331-73480734 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021556	protein coding gene	Chr14:67975401-67980795 (+)
A/J	MGP_AJ_G0021515	protein coding gene	Chr14:66489571-66494970 (+)
AKR/J	MGP_AKRJ_G0021491	protein coding gene	Chr14:68441454-68446857 (+)
BALB/cJ	MGP_BALBcJ_G0021521	protein coding gene	Chr14:66252971-66258370 (+)
C3H/HeJ	MGP_C3HHeJ_G0021298	protein coding gene	Chr14:68167126-68172533 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021962	protein coding gene	Chr14:70968074-70973473 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019500	protein coding gene	Chr14:64210444-64215775 (+)
CAST/EiJ	MGP_CASTEiJ_G0020816	protein coding gene	Chr14:64827212-64832573 (+)
CBA/J	MGP_CBAJ_G0021266	protein coding gene	Chr14:73196707-73202098 (+)
DBA/2J	MGP_DBA2J_G0021389	protein coding gene	Chr14:65873011-65878420 (+)
FVB/NJ	MGP_FVBNJ_G0021367	protein coding gene	Chr14:65253343-65258665 (+)
LP/J	MGP_LPJ_G0021459	protein coding gene	Chr14:69144120-69149465 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021396	protein coding gene	Chr14:72026750-72033136 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021984	protein coding gene	Chr14:67715683-67721082 (+)
PWK/PhJ	MGP_PWKPhJ_G0020559	protein coding gene	Chr14:62642150-62647495 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020394	protein coding gene	Chr14:63683005-63688369 (+)
WSB/EiJ	MGP_WSBEiJ_G0020869	protein coding gene	Chr14:68066268-68072800 (+)

Human Ortholog

LPAR6, lysophosphatidic acid receptor 6

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LPAR6, lysophosphatidic acid receptor 6
Synonyms

ARWH1, HYPT8, LAH3, LPA-6, P2RY5, P2Y5
Links

HGNC:15520

NCBI Gene ID: 10161

neXtProt AC: NX_P43657

UniProt: P43657
Chr Location

13q14.2; chr13:48389567-48444704 (-) GRCh38

MGI Vertebrate Homology

Lpar6 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LPAR6
Gene Tree

Lpar6

Diseases

1 with human LPAR6 associations

				Human Disease	Mouse Models
				hypotrichosis 8 IDs hypotrichosis 8 DOID:0110705 OMIM:278150

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

7
Targeted

11
Genomic Mutations

1 involving Lpar6
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show dysregulated basal-to-luminal urothelial differentiation, with hyperplasia of the luminal cells in the bladder urothelium, and show increased susceptibility to tobacco-related carcinogen BBN-induced luminal-type bladder cancer.

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

842
Tissues

74
cDNA Data

56
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lpar6

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All Sequences

37
RefSeq

2
UniProt

1
CCDS

CCDS27268.1

Ensembl

ENSMUSG00000033446 (Evidence)
NCBI Gene

67168

			Length	Strain/Species	Flank
genomic	67168	NCBI Gene Model \| MGI Sequence Detail	2468	C57BL/6J	± kb
transcript	NM_175116	RefSeq \| MGI Sequence Detail	2468	C57BL/6
polypeptide	Q8BMC0	UniProt \| EBI \| MGI Sequence Detail	344	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001632 oleoyl-L-alpha-lysophosphatidic acid receptor

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

Q8BMC0 4 sites

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All nucleic 64

cDNA 56

Primer pair 7

Other 1

Microarray probesets 4

Summaries

All 56

Developmental Gene Expression 8

Gene Ontology 5

Phenotypes 24
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11

TSS for Lpar6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126540	Chr14:73475429-73475447 (+)	107 bp
Tssr126541	Chr14:73475450-73475461 (+)	125 bp
Tssr126542	Chr14:73475593-73475605 (+)	268 bp
Tssr126543	Chr14:73476496-73476509 (+)	1,172 bp
Tssr126544	Chr14:73476610-73476630 (+)	1,289 bp
Tssr126545	Chr14:73476835-73476879 (+)	1,526 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24