Ube2t MGI Mouse Gene Detail - MGI:1914446 - ubiquitin-conjugating enzyme E2T

Symbol

Ube2t
Name

ubiquitin-conjugating enzyme E2T
Synonyms

2700084L22Rik

Feature Type

protein coding gene
IDs

MGI:1914446
NCBI Gene: 67196
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:134890303-134901900 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 58.24 cM
Mapping Data

2 experiments

SNPs within 2kb

423 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914446	protein coding gene	Chr1:134890303-134901918 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016514	protein coding gene	Chr1:138686116-138699245 (+)
A/J	MGP_AJ_G0016497	protein coding gene	Chr1:133447913-133460826 (+)
AKR/J	MGP_AKRJ_G0016462	protein coding gene	Chr1:137426944-137438845 (+)
BALB/cJ	MGP_BALBcJ_G0016457	protein coding gene	Chr1:133766630-133778299 (+)
C3H/HeJ	MGP_C3HHeJ_G0016283	protein coding gene	Chr1:137518153-137532214 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016918	protein coding gene	Chr1:143710545-143723682 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014629	protein coding gene	Chr1:126564343-126576175 (+)
CAST/EiJ	MGP_CASTEiJ_G0015863	protein coding gene	Chr1:136589496-136601595 (+)
CBA/J	MGP_CBAJ_G0016256	protein coding gene	Chr1:148659662-148673521 (+)
DBA/2J	MGP_DBA2J_G0016362	protein coding gene	Chr1:132453512-132465348 (+)
FVB/NJ	MGP_FVBNJ_G0016361	protein coding gene	Chr1:131089226-131101023 (+)
LP/J	MGP_LPJ_G0016433	protein coding gene	Chr1:139931964-139944833 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016386	protein coding gene	Chr1:154363313-154379753 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016954	protein coding gene	Chr1:137165460-137180685 (+)
PWK/PhJ	MGP_PWKPhJ_G0015649	protein coding gene	Chr1:131475494-131487957 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015436	protein coding gene	Chr1:136133591-136145425 (+)
WSB/EiJ	MGP_WSBEiJ_G0015926	protein coding gene	Chr1:137194742-137207521 (+)

Human Ortholog

UBE2T, ubiquitin conjugating enzyme E2 T

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBE2T, ubiquitin conjugating enzyme E2 T
Synonyms

FANCT, HSPC150, PIG50
Links

HGNC:25009

NCBI Gene ID: 29089

neXtProt AC: NX_Q9NPD8

UniProt: Q9NPD8
Chr Location

1q32.1; chr1:202331544-202341984 (-) GRCh38

MGI Vertebrate Homology

Ube2t stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UBE2T
Gene Tree

Ube2t

Diseases

1 with human UBE2T associations

				Human Disease	Mouse Models
				Fanconi anemia complementation group T IDs Fanconi anemia complementation group T DOID:0111081 OMIM:616435

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotype references

All Mutations and Alleles

27
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

14
Radiation induced

1
Targeted

6
Genomic Mutations

3 involving Ube2t
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available

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All GO Annotations

36
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

793
Tissues

16
cDNA Data

39
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ube2t

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All Sequences

45
RefSeq

4
UniProt

3
CCDS

CCDS15313.1

Ensembl

ENSMUSG00000026429 (Evidence)
NCBI Gene

67196

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026429	Ensembl Gene Model \| MGI Sequence Detail	11598	C57BL/6J	± kb
transcript	ENSMUST00000027687	Ensembl \| MGI Sequence Detail	1116	Not Applicable
polypeptide	ENSMUSP00000027687	Ensembl \| MGI Sequence Detail	204	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016988 ubiquitin-conjugating enzyme E2 T

(term hierarchy)
EC

2.3.2.23
InterPro Domains

IPR050113 Ubiquitin-conjugating enzyme

IPR023313 Ubiquitin-conjugating enzyme, active site

IPR000608 Ubiquitin-conjugating enzyme E2

IPR016135 Ubiquitin-conjugating enzyme/RWD-like

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All nucleic 39

cDNA 39

Microarray probesets 3

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MGI:2138694

Summaries

All 44

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 14
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Ube2t:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8922	Chr1:134890291-134890306 (+)	-4 bp
Tssr8923	Chr1:134890309-134890365 (+)	34 bp
Tssr8924	Chr1:134890369-134890380 (+)	72 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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