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Eif2s2 Gene Detail
Summary
  • Symbol
    Eif2s2
  • Name
    eukaryotic translation initiation factor 2 subunit 2 beta
  • Synonyms
    2810026E11Rik, 38kDa, D2Ertd303e, EIF2, EIF2B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914454
    NCBI Gene: 67204
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:154713330-154734826 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 76.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    436 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914454
 protein coding gene Chr2:154713330-154734855 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026727
 protein coding gene Chr2:159655964-159677940 (-)
A/J MGP_AJ_G0026692
 protein coding gene Chr2:153286347-153308281 (-)
AKR/J MGP_AKRJ_G0026664
 protein coding gene Chr2:157751134-157773780 (-)
BALB/cJ MGP_BALBcJ_G0026702
 protein coding gene Chr2:153595283-153619539 (-)
C3H/HeJ MGP_C3HHeJ_G0026445
 protein coding gene Chr2:158105623-158135928 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027151
 protein coding gene Chr2:164310707-164332649 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024521
 protein coding gene Chr2:146811192-146831996 (-)
CAST/EiJ MGP_CASTEiJ_G0025905
 protein coding gene Chr2:158438361-158458634 (-)
CBA/J MGP_CBAJ_G0026422
 protein coding gene Chr2:170299098-170323565 (-)
DBA/2J MGP_DBA2J_G0026559
 protein coding gene Chr2:152499622-152521848 (-)
FVB/NJ MGP_FVBNJ_G0026525
 protein coding gene Chr2:150895825-150920724 (-)
LP/J MGP_LPJ_G0026664
 protein coding gene Chr2:159779238-159799628 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026547
 protein coding gene Chr2:174325122-174347347 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027207
 protein coding gene Chr2:157625872-157647848 (-)
PWK/PhJ MGP_PWKPhJ_G0025639
 protein coding gene Chr2:151997398-152017539 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025443
 protein coding gene Chr2:156582724-156603053 (-)
WSB/EiJ MGP_WSBEiJ_G0025976
 protein coding gene Chr2:158554650-158574945 (-)



Homology
more
  • Human Ortholog
    EIF2S2, eukaryotic translation initiation factor 2 subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF2S2, eukaryotic translation initiation factor 2 subunit beta
  • Synonyms
    EIF2, EIF2B, eIF-2-beta, EIF2beta, PPP1R67
  • Links
    NCBI Gene ID: 8894
    neXtProt AC: NX_P20042
    UniProt: P20042

  • Chr Location
    20q11.22; chr20:34088309-34112243 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit embryonic lethallity prior to E8.5. Mice heterozygous for a gene trap allele exhibit reduced incidence of testicular germ cell tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    16
  • cDNA Data
    23
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67204 NCBI Gene Model | MGI Sequence Detail 21497 C57BL/6J ±  kb
    transcript NM_026030 RefSeq | MGI Sequence Detail 2513 C57BL/6  
    polypeptide Q99L45 UniProt | EBI | MGI Sequence Detail 331 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000006972 eukaryotic translation initiation factor 2 subunit 2
      (term hierarchy)
    • InterPro Domains
      IPR045196 Translation initiation factor IF2/IF5
      IPR002735 Translation initiation factor IF2/IF5 domain
      IPR016189 Translation initiation factor IF2/IF5, N-terminal
      IPR016190 Translation initiation factor IF2/IF5, zinc-binding
    • GlyGen
      Q99L45 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 24
      Primer pair 2
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1098790, MGI:2138753, MGI:2138795, MGI:2138820, MGI:2139418
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 48
    • Earliest
      J:2300 Charles CH, et al., cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein. Oncogene. 1992 Jan;7(1):187-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory