Gemin6 MGI Mouse Gene Detail - MGI:1914492 - gem nuclear organelle associated protein 6

Symbol

Gemin6
Name

gem nuclear organelle associated protein 6
Synonyms

2610019B15Rik, 2810470M17Rik

Feature Type

protein coding gene
IDs

MGI:1914492
NCBI Gene: 67242
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr17:80531870-80535926 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 50.63 cM, cytoband E3
Mapping Data

2 experiments

SNPs within 2kb

195 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914492	protein coding gene	Chr17:80514933-80535926 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024059	protein coding gene	Chr17:83134283-83138339 (+)
A/J	MGP_AJ_G0024016	protein coding gene	Chr17:80578718-80582792 (+)
AKR/J	MGP_AKRJ_G0023985	protein coding gene	Chr17:81837348-81841415 (+)
BALB/cJ	MGP_BALBcJ_G0024018	protein coding gene	Chr17:80456223-80460450 (+)
C3H/HeJ	MGP_C3HHeJ_G0023782	protein coding gene	Chr17:82716818-82720865 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024462	protein coding gene	Chr17:86166304-86174325 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030803	protein coding gene	Chr8:1794898-1796196 (-)
CAST/EiJ	MGP_CASTEiJ_G0023262	protein coding gene	Chr17:83392927-83400161 (+)
CBA/J	MGP_CBAJ_G0023756	protein coding gene	Chr17:89749320-89753349 (+)
DBA/2J	MGP_DBA2J_G0023885	protein coding gene	Chr17:79087756-79091805 (+)
FVB/NJ	MGP_FVBNJ_G0023851	protein coding gene	Chr17:78588170-78592226 (+)
LP/J	MGP_LPJ_G0023968	protein coding gene	Chr17:83974770-83978828 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023879	protein coding gene	Chr17:89802518-89807191 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024507	protein coding gene	Chr17:82319668-82341094 (+)
PWK/PhJ	MGP_PWKPhJ_G0023008	protein coding gene	Chr17:78623637-78627919 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022819	protein coding gene	Chr17:79099854-79103929 (+)
WSB/EiJ	MGP_WSBEiJ_G0023329	protein coding gene	Chr17:83139999-83144995 (+)

Human Ortholog

GEMIN6, gem nuclear organelle associated protein 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GEMIN6, gem nuclear organelle associated protein 6
Links

HGNC:20044

NCBI Gene ID: 79833

neXtProt AC: NX_Q8WXD5

UniProt: Q8WXD5
Chr Location

2p22.1; chr2:38751534-38785002 (+) GRCh38

MGI Vertebrate Homology

Gemin6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GEMIN6
Gene Tree

Gemin6

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Phenotype Summary

2 phenotypes from 1 allele in 2 genetic backgrounds
1 images
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Endonuclease-mediated

2
Gene trapped

30
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available

Mice homozygous for a knock-out allele exhibit complete embryonic lethality between implantation and somite formation.

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All GO Annotations

19
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

6
cDNA Data

44
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gemin6

ZFIN gemin6

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All Sequences

42
RefSeq

6
UniProt

1
CCDS

CCDS28989.1

Ensembl

ENSMUSG00000055760 (Evidence)
NCBI Gene

67242

			Length	Strain/Species	Flank
genomic	ENSMUSG00000055760	Ensembl Gene Model \| MGI Sequence Detail	4057	C57BL/6J	± kb
transcript	ENSMUST00000069486	Ensembl \| MGI Sequence Detail	1134	Not Applicable
polypeptide	ENSMUSP00000063554	Ensembl \| MGI Sequence Detail	166	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007935 gem-associated protein 6

(term hierarchy)
InterPro Domains

IPR047574 AD domain

IPR009422 Gem-associated protein 6

IPR046856 Gem-associated protein 6, C-terminal domain

IPR046857 Gem-associated protein 6, Sm-like domain

IPR047575 Sm domain
GlyGen

Q9CX53 1 site, 1 O-linked glycan (1 site)

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All nucleic 44

cDNA 44

Microarray probesets 4

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MGI:1916458

Summaries

All 37

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gemin6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145954	Chr17:80531876-80531922 (+)	29 bp
Tssr145955	Chr17:80531924-80531939 (+)	62 bp
Tssr145956	Chr17:80531945-80531954 (+)	80 bp
Tssr145957	Chr17:80531962-80531979 (+)	101 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24