Pagr1a MGI Mouse Gene Detail - MGI:1914528 - PAXIP1 associated glutamate rich protein 1A

Symbol

Pagr1a
Name

PAXIP1 associated glutamate rich protein 1A
Synonyms

2900092E17Rik, C77040, PA1

Feature Type

protein coding gene
IDs

MGI:1914528
NCBI Gene: 67278
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr7:126614223-126616524 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 69.27 cM, cytoband F4
Mapping Data

3 experiments

SNPs within 2kb

104 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914528	protein coding gene	Chr7:126614205-126616524 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033014	protein coding gene	Chr7:131329225-131331544 (-)
A/J	MGP_AJ_G0032997	protein coding gene	Chr7:127842630-127844949 (-)
AKR/J	MGP_AKRJ_G0032929	protein coding gene	Chr7:131078313-131080632 (-)
BALB/cJ	MGP_BALBcJ_G0033002	protein coding gene	Chr7:127506052-127508371 (-)
C3H/HeJ	MGP_C3HHeJ_G0032712	protein coding gene	Chr7:131020777-131023096 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033508	protein coding gene	Chr7:136433541-136435860 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030480	protein coding gene	Chr7:129055079-129057373 (-)
CAST/EiJ	MGP_CASTEiJ_G0032041	protein coding gene	Chr7:122810339-122812656 (-)
CBA/J	MGP_CBAJ_G0032685	protein coding gene	Chr7:141021451-141023770 (-)
DBA/2J	MGP_DBA2J_G0032837	protein coding gene	Chr7:125816684-125819003 (-)
FVB/NJ	MGP_FVBNJ_G0032790	protein coding gene	Chr7:125668009-125670328 (-)
LP/J	MGP_LPJ_G0032931	protein coding gene	Chr7:132799800-132802119 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032822	protein coding gene	Chr7:142187344-142189663 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033527	protein coding gene	Chr7:130094932-130097251 (-)
PWK/PhJ	MGP_PWKPhJ_G0031748	protein coding gene	Chr7:118813327-118815646 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031594	protein coding gene	Chr7:116935695-116938049 (-)
WSB/EiJ	MGP_WSBEiJ_G0032153	protein coding gene	Chr7:131070571-131072890 (-)

Human Ortholog

PAGR1, PAXIP1 associated glutamate rich protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PAGR1, PAXIP1 associated glutamate rich protein 1
Synonyms

C16orf53, GAS, PA1
Links

HGNC:28707

NCBI Gene ID: 79447

neXtProt AC: NX_Q9BTK6

UniProt: Q9BTK6
Chr Location

16p11.2; chr16:29816152-29822489 (+) GRCh38

MGI Vertebrate Homology

Pagr1a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PAGR1
Gene Tree

Pagr1a

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References

3 with disease annotations

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Phenotype Summary

21 phenotypes from 1 allele in 1 genetic background
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Targeted

11
Genomic Mutations

5 involving Pagr1a
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele fail to undergo axial rotation and show abnormal embryonic and extraembryonic tissue development, defects in amnion, chorion and visceral yolk sac morphology, abnormal rostral-caudal body axis extension, growth arrest, and complete embryonic lethality.

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All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

726
Tissues

11
cDNA Data

64
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

2
UniProt

1
CCDS

CCDS21854.1

Ensembl

ENSMUSG00000030680 (Evidence)
NCBI Gene

67278

			Length	Strain/Species	Flank
genomic	67278	NCBI Gene Model \| MGI Sequence Detail	2302	C57BL/6J	± kb
transcript	NM_030240	RefSeq \| MGI Sequence Detail	1448	Not Specified
polypeptide	Q99L02	UniProt \| EBI \| MGI Sequence Detail	253	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000012201 PAXIP1-associated glutamate-rich protein 1

(term hierarchy)

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All nucleic 64

cDNA 64

Microarray probesets 7

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MGI:2142311

Summaries

All 71

Developmental Gene Expression 1

Diseases 3

Gene Ontology 8

Phenotypes 42
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:349484 Henis M, et al., The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation. Sci Adv. 2024 Apr 12;10(15):eadf7001

TSS for Pagr1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr74889	Chr7:126618091-126618098 (-)	-1,571 bp
Tssr74888	Chr7:126617750-126617768 (-)	-1,235 bp
Tssr74887	Chr7:126617738-126617749 (-)	-1,220 bp
Tssr74886	Chr7:126617644-126617695 (-)	-1,146 bp
Tssr74885	Chr7:126616536-126616564 (-)	-26 bp
Tssr74884	Chr7:126616473-126616515 (-)	30 bp
Tssr74883	Chr7:126616438-126616464 (-)	73 bp
Tssr74882	Chr7:126616423-126616434 (-)	95 bp
Tssr74881	Chr7:126616207-126616236 (-)	302 bp
Tssr74880	Chr7:126616174-126616204 (-)	335 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24