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Cwc27 Gene Detail
Summary
  • Symbol
    Cwc27
  • Name
    CWC27 spliceosome-associated protein
  • Synonyms
    3110009E13Rik, NY-CO-10, Sdccag10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914535
    NCBI Gene: 67285
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:104767648-104953649 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 56.64 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3780 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914535
 protein coding gene Chr13:104767648-104953650 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020909
 protein coding gene Chr13:106741328-106930688 (-)
A/J MGP_AJ_G0020860
 protein coding gene Chr13:102589814-102774268 (-)
AKR/J MGP_AKRJ_G0020835
 protein coding gene Chr13:105708773-105895362 (-)
BALB/cJ MGP_BALBcJ_G0020860
 protein coding gene Chr13:103304852-103479410 (-)
C3H/HeJ MGP_C3HHeJ_G0020649
 protein coding gene Chr13:105454375-105643191 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021294
 protein coding gene Chr13:109960969-110150970 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018864
 protein coding gene Chr13:98185421-98357947 (-)
CAST/EiJ MGP_CASTEiJ_G0020168
 protein coding gene Chr13:104948831-105140253 (-)
CBA/J MGP_CBAJ_G0020611
 protein coding gene Chr13:114213998-114415565 (-)
DBA/2J MGP_DBA2J_G0020735
 protein coding gene Chr13:102354855-102531777 (-)
FVB/NJ MGP_FVBNJ_G0020717
 protein coding gene Chr13:101049974-101229236 (-)
LP/J MGP_LPJ_G0020809
 protein coding gene Chr13:106773267-106961726 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020745
 protein coding gene Chr13:114479859-114675485 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021333
 protein coding gene Chr13:105185641-105368395 (-)
PWK/PhJ MGP_PWKPhJ_G0019921
 protein coding gene Chr13:101096521-101267214 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019743
 protein coding gene Chr13:101395323-101578984 (-)
WSB/EiJ MGP_WSBEiJ_G0020226
 protein coding gene Chr13:105658066-105844893 (-)



Homology
more
  • Human Ortholog
    CWC27, CWC27 spliceosome associated cyclophilin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CWC27, CWC27 spliceosome associated cyclophilin
  • Synonyms
    NY-CO-10, RPSKA, SDCCAG-10, SDCCAG10
  • Links
    NCBI Gene ID: 10283
    neXtProt AC: NX_Q6UX04
    UniProt: Q6UX04

  • Chr Location
    5q12.3; chr5:64766368-65102412 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cwc27 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit reduced viability. Surviors after birth show signs of growth retardation and retinal depigmentation, along with numerous neurological, immunological, and blood chemistry abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    12
  • cDNA Data
    27
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67285 NCBI Gene Model | MGI Sequence Detail 186002 C57BL/6J ±  kb
    transcript NM_001360094 RefSeq | MGI Sequence Detail 2080 C57BL/6  
    polypeptide Q3TKY6 UniProt | EBI | MGI Sequence Detail 469 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000014557 spliceosome-associated protein CWC27 homolog
      (term hierarchy)
    • EC
      5.2.1.8
    • InterPro Domains
      IPR029000 Cyclophilin-like domain superfamily
      IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
      IPR044666 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like
      IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
    • GlyGen
      Q3TKY6 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 27

      Microarray probesets 2
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 21
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory