Snrpd3 MGI Mouse Gene Detail - MGI:1914582 - small nuclear ribonucleoprotein D3

Symbol

Snrpd3
Name

small nuclear ribonucleoprotein D3
Synonyms

1700043E15Rik, 2310009E13Rik, SMD3

Feature Type

protein coding gene
IDs

MGI:1914582
NCBI Gene: 67332
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:75353852-75371300 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 38.55 cM
Mapping Data

2 experiments

SNPs within 2kb

454 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914582	protein coding gene	Chr10:75353385-75373215 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017356	protein coding gene	Chr10:75692972-75712875 (+)
A/J	MGP_AJ_G0017333	protein coding gene	Chr10:73096246-73116082 (+)
AKR/J	MGP_AKRJ_G0017294	protein coding gene	Chr10:75057942-75077762 (+)
BALB/cJ	MGP_BALBcJ_G0017293	protein coding gene	Chr10:73290248-73310085 (+)
C3H/HeJ	MGP_C3HHeJ_G0017117	protein coding gene	Chr10:75094906-75114725 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017751	protein coding gene	Chr10:78376817-78396645 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015441	protein coding gene	Chr10:69555132-69574686 (+)
CAST/EiJ	MGP_CASTEiJ_G0016688	protein coding gene	Chr10:75407895-75428960 (+)
CBA/J	MGP_CBAJ_G0017089	protein coding gene	Chr10:81441582-81461399 (+)
DBA/2J	MGP_DBA2J_G0017194	protein coding gene	Chr10:72395633-72415504 (+)
FVB/NJ	MGP_FVBNJ_G0017187	protein coding gene	Chr10:71534822-71554469 (+)
LP/J	MGP_LPJ_G0017267	protein coding gene	Chr10:76181024-76203235 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017215	protein coding gene	Chr10:83543195-83563049 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017790	protein coding gene	Chr10:75079963-75100555 (+)
PWK/PhJ	MGP_PWKPhJ_G0016471	protein coding gene	Chr10:72218219-72239225 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016254	protein coding gene	Chr10:74329028-74348421 (+)
WSB/EiJ	MGP_WSBEiJ_G0016751	protein coding gene	Chr10:75054696-75074282 (+)

Human Ortholog

SNRPD3, small nuclear ribonucleoprotein D3 polypeptide

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SNRPD3, small nuclear ribonucleoprotein D3 polypeptide
Synonyms

Sm-D3, SMD3
Links

HGNC:11160

NCBI Gene ID: 6634

neXtProt AC: NX_P62318

UniProt: P62318
Chr Location

22q11.23; chr22:24555650-24582052 (+) GRCh38

MGI Vertebrate Homology

Snrpd3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SNRPD3
Gene Tree

Snrpd3

Diseases

1 with human SNRPD3 associations

				Human Disease	Mouse Models
				systemic lupus erythematosus IDs systemic lupus erythematosus DOID:9074 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 UMLS_CUI:C0024141

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotype references

All Mutations and Alleles

20
Chemically induced (other)

1
Gene trapped

19
Genomic Mutations

1 involving Snrpd3
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

6 strains or lines available

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All GO Annotations

60
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SNRPD3

Xenbase snrpd3

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All Sequences

40
RefSeq

2
UniProt

3
CCDS

CCDS23926.1

Ensembl

ENSMUSG00000020180 (Evidence)
NCBI Gene

67332

			Length	Strain/Species	Flank
genomic	67332	NCBI Gene Model \| MGI Sequence Detail	17449	C57BL/6J	± kb
transcript	NM_026095	RefSeq \| MGI Sequence Detail	654	C57BL/6
polypeptide	P62320	UniProt \| EBI \| MGI Sequence Detail	126	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015345 small nuclear ribonucleoprotein Sm D3

(term hierarchy)
InterPro Domains

IPR027141 Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3

IPR010920 LSM domain superfamily

IPR034099 Small nuclear ribonucleoprotein Sm D3

IPR047575 Sm domain

IPR001163 Sm domain, eukaryotic/archaea-type
GlyGen

P62320 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 11

cDNA 11

Microarray probesets 6

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MGI:1925629, MGI:2143794

Summaries

All 43

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 10
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:189260 Scruggs BS, et al., SmD3 Regulates Intronic Noncoding RNA Biogenesis. Mol Cell Biol. 2012 Oct;32(20):4092-103

TSS for Snrpd3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94106	Chr10:75353379-75353391 (+)	-467 bp
Tssr94107	Chr10:75353845-75353863 (+)	2 bp
Tssr94108	Chr10:75353864-75353875 (+)	18 bp
Tssr94109	Chr10:75353876-75353880 (+)	26 bp
Tssr94110	Chr10:75367842-75367860 (+)	13,999 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24