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Erp29 Gene Detail
Summary
  • Symbol
    Erp29
  • Name
    endoplasmic reticulum protein 29
  • Synonyms
    1200015M03Rik, 2810446M09Rik, Erp28, Erp31, PDI-Db
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914647
    NCBI Gene: 67397
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:121582816-121590537 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 61.80 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    261 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914647
 protein coding gene Chr5:121566653-121590569 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030027
 protein coding gene Chr5:124913608-124937491 (-)
A/J MGP_AJ_G0029992
 protein coding gene Chr5:119770429-119794313 (-)
AKR/J MGP_AKRJ_G0029929
 protein coding gene Chr5:123645731-123669641 (-)
BALB/cJ MGP_BALBcJ_G0030003
 protein coding gene Chr5:121153993-121177877 (-)
C3H/HeJ MGP_C3HHeJ_G0029721
 protein coding gene Chr5:124210025-124233936 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030456
 protein coding gene Chr5:129672861-129696777 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027682
 protein coding gene Chr5:114462888-114474968 (-)
CAST/EiJ MGP_CASTEiJ_G0029129
 protein coding gene Chr5:123322435-123346378 (-)
CBA/J MGP_CBAJ_G0029690
 protein coding gene Chr5:134766418-134794463 (-)
DBA/2J MGP_DBA2J_G0029840
 protein coding gene Chr5:119841569-119865485 (-)
FVB/NJ MGP_FVBNJ_G0029797
 protein coding gene Chr5:118789592-118813506 (-)
LP/J MGP_LPJ_G0029929
 protein coding gene Chr5:125431511-125455395 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029827
 protein coding gene Chr5:138630102-138654048 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030497
 protein coding gene Chr5:123159464-123184930 (-)
PWK/PhJ MGP_PWKPhJ_G0028843
 protein coding gene Chr5:118611637-118636214 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028680
 protein coding gene Chr5:120924995-120950034 (-)
WSB/EiJ MGP_WSBEiJ_G0029204
 protein coding gene Chr5:123816839-123840706 (-)



Homology
more
  • Human Ortholog
    ERP29, endoplasmic reticulum protein 29
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERP29, endoplasmic reticulum protein 29
  • Synonyms
    C12orf8, ERp28, ERp31, HEL-S-107, PDIA9, PDI-DB
  • Links
    NCBI Gene ID: 10961
    neXtProt AC: NX_P30040
    UniProt: P30040

  • Chr Location
    12q24.13; chr12:112013348-112023449 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    34
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    27
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Erp29
  • Find Mice (IMSR)
    33 strains or lines available
Mice homozygous for a null allele exhibit decreased thyrocyte and dermal fibroblast apoptosis sensitivities to induced ER stress and slightly reduced litter sizes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    2
  • cDNA Data
    12
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67397 NCBI Gene Model | MGI Sequence Detail 7722 C57BL/6J ±  kb
transcript NM_026129 RefSeq | MGI Sequence Detail 1258 Not Specified  
polypeptide P57759 UniProt | EBI | MGI Sequence Detail 262 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000007190 endoplasmic reticulum resident protein 29
    (term hierarchy)
  • InterPro Domains
    IPR016855 Endoplasmic reticulum resident protein 29
    IPR011679 Endoplasmic reticulum resident protein 29, C-terminal
    IPR036356 Endoplasmic reticulum resident protein 29, C-terminal domain superfamily
    IPR012883 ERp29, N-terminal
    IPR036249 Thioredoxin-like superfamily
  • GlyGen
    P57759 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 6
Other
Accession IDs
less
MGI:1920007, MGI:2141173
References
more
  • Summaries
    All 58
    Developmental Gene Expression 3
    Gene Ontology 10
    Phenotypes 18
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:247892 Zhang Y, et al., Proteomic identification of ERP29 as a key chemoresistant factor activated by the aggregating p53 mutant Arg282Trp. Oncogene. 2017 Sep 28;36(39):5473-5483
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory