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Srpra Gene Detail
Summary
  • Symbol
    Srpra
  • Name
    signal recognition particle receptor alpha
  • Synonyms
    1300011P19Rik, D11Mgi27, Srpr
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914648
    NCBI Gene: 67398
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:35122499-35128299 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 20.06 cM, cytoband A5.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    195 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914648
 protein coding gene Chr9:35111471-35159269 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034531
 protein coding gene Chr9:33004768-33052351 (+)
A/J MGP_AJ_G0034509
 protein coding gene Chr9:32151409-32196107 (+)
AKR/J MGP_AKRJ_G0034435
 protein coding gene Chr9:32874918-32923666 (+)
BALB/cJ MGP_BALBcJ_G0034500
 protein coding gene Chr9:32067660-32113005 (+)
C3H/HeJ MGP_C3HHeJ_G0034212
 protein coding gene Chr9:33211144-33259759 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035021
 protein coding gene Chr9:34116480-34162340 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031951
 protein coding gene Chr9:30840109-30887555 (+)
CAST/EiJ MGP_CASTEiJ_G0033535
 protein coding gene Chr9:33101568-33162015 (+)
CBA/J MGP_CBAJ_G0034186
 protein coding gene Chr9:35266938-35316754 (+)
DBA/2J MGP_DBA2J_G0034343
 protein coding gene Chr9:32132955-32179248 (+)
FVB/NJ MGP_FVBNJ_G0034286
 protein coding gene Chr9:31546934-31593090 (+)
LP/J MGP_LPJ_G0034429
 protein coding gene Chr9:33256040-33305259 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034330
 protein coding gene Chr9:36840670-36890487 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035041
 protein coding gene Chr9:32824616-32876505 (+)
PWK/PhJ MGP_PWKPhJ_G0033240
 protein coding gene Chr9:32118690-32165592 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033075
 protein coding gene Chr9:32974154-32993839 (+)
WSB/EiJ MGP_WSBEiJ_G0033650
 protein coding gene Chr9:32593628-32643093 (+)



Homology
more
  • Human Ortholog
    SRPRA, SRP receptor subunit alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRPRA, SRP receptor subunit alpha
  • Synonyms
    DP, Sralpha, SRPR
  • Links
    NCBI Gene ID: 6734
    neXtProt AC: NX_P08240
    UniProt: P08240

  • Chr Location
    11q24.2; chr11:126235930-126269144 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    15
  • cDNA Data
    239
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67398 NCBI Gene Model | MGI Sequence Detail 5801 C57BL/6J ±  kb
transcript NM_026130 RefSeq | MGI Sequence Detail 2934 C57BL/6  
polypeptide Q9DBG7 UniProt | EBI | MGI Sequence Detail 636 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000015632 signal recognition particle receptor subunit alpha
    (term hierarchy)
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR011012 Longin-like domain superfamily
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR007222 Signal recognition particle receptor, alpha subunit, N-terminal
    IPR013822 Signal recognition particle SRP54, helical bundle
    IPR042101 Signal recognition particle SRP54, N-terminal domain superfamily
    IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain
    IPR036225 SRP/SRP receptor, N-terminal
  • GlyGen
    Q9DBG7 2 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 239
    cDNA 239

    Microarray probesets 5
Other
Accession IDs
less
MGI:2681058, MGI:7529687
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:197701 Lang S, et al., Different effects of Sec61alpha, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J Cell Sci. 2012 Apr 15;125(Pt 8):1958-69
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory