About   Help   FAQ
Cylc1 Gene Detail
Summary
  • Symbol
    Cylc1
  • Name
    cylicin, basic protein of sperm head cytoskeleton 1
  • Synonyms
    4930401M13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914657
    NCBI Gene: 67407
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:110154024-110169624 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 48.20 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    314 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914657
 protein coding gene ChrX:110154024-110169731 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036025
 protein coding gene ChrX:107965407-107978571 (+)
A/J MGP_AJ_G0036005
 protein coding gene ChrX:107861605-107880276 (+)
AKR/J MGP_AKRJ_G0035924
 protein coding gene ChrX:111184800-111203384 (+)
BALB/cJ MGP_BALBcJ_G0035996
 protein coding gene ChrX:106481147-106494103 (+)
C3H/HeJ MGP_C3HHeJ_G0035702
 protein coding gene ChrX:108417685-108438558 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036521
 protein coding gene ChrX:111100978-111118818 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033349
 protein coding gene ChrX:104692349-104703528 (+)
CAST/EiJ MGP_CASTEiJ_G0034988
 protein coding gene ChrX:92357320-92369926 (+)
CBA/J MGP_CBAJ_G0035678
 protein coding gene ChrX:114617594-114627779 (+)
DBA/2J MGP_DBA2J_G0035831
 protein coding gene ChrX:106997539-107012337 (+)
FVB/NJ MGP_FVBNJ_G0035772
 protein coding gene ChrX:106369551-106391942 (+)
LP/J MGP_LPJ_G0035924
 protein coding gene ChrX:108867570-108880179 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035803
 protein coding gene ChrX:119886153-119900270 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036548
 protein coding gene ChrX:107516076-107529659 (+)
PWK/PhJ MGP_PWKPhJ_G0034684
 protein coding gene ChrX:89886317-89900328 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034513
 protein coding gene ChrX:93195135-93214724 (+)
WSB/EiJ MGP_WSBEiJ_G0035126
 protein coding gene ChrX:106210704-106223632 (+)



Homology
more
  • Human Ortholog
    CYLC1, cylicin 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYLC1, cylicin 1
  • Synonyms
    CYCL1, SPGFX8
  • Links
    NCBI Gene ID: 1538
    neXtProt AC: NX_P35663
    UniProt: P35663

  • Chr Location
    Xq21.1; chrX:83861126-83886699 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cylc1 mouse models; 1 with human CYLC1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation reduced male fertility with detached acrosomes, fan-shaped sperm heads, and impaired fertilization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67407 NCBI Gene Model | MGI Sequence Detail 15601 C57BL/6J ±  kb
    transcript NM_026134 RefSeq | MGI Sequence Detail 1969 C57BL/6  
    polypeptide A0A1B0GR13 UniProt | EBI | MGI Sequence Detail 642 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 20
      Diseases 1
      Gene Ontology 4
      Phenotypes 3
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:347872 Jin HJ, et al., Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice. Elife. 2024 Apr 4;13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory