Far1 MGI Mouse Gene Detail - MGI:1914670 - fatty acyl CoA reductase 1

Symbol

Far1
Name

fatty acyl CoA reductase 1
Synonyms

2600011M19Rik, 2900034E22Rik, 3732409C05Rik, Mlstd2

Feature Type

protein coding gene
IDs

MGI:1914670
NCBI Gene: 67420
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr7:113113041-113170718 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 59.21 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

1075 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914670	protein coding gene	Chr7:113113008-113170718 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032876	protein coding gene	Chr7:117154940-117214555 (+)
A/J	MGP_AJ_G0032859	protein coding gene	Chr7:114211355-114269643 (+)
AKR/J	MGP_AKRJ_G0032791	protein coding gene	Chr7:117082636-117141130 (+)
BALB/cJ	MGP_BALBcJ_G0032864	protein coding gene	Chr7:113906249-113967045 (+)
C3H/HeJ	MGP_C3HHeJ_G0032574	protein coding gene	Chr7:117077145-117136371 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033370	protein coding gene	Chr7:121884900-121943063 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030342	protein coding gene	Chr7:115760501-115817564 (+)
CAST/EiJ	MGP_CASTEiJ_G0031902	protein coding gene	Chr7:108700825-108766179 (+)
CBA/J	MGP_CBAJ_G0032547	protein coding gene	Chr7:125927925-125987693 (+)
DBA/2J	MGP_DBA2J_G0032699	protein coding gene	Chr7:112273748-112331164 (+)
FVB/NJ	MGP_FVBNJ_G0032652	protein coding gene	Chr7:112133061-112190198 (+)
LP/J	MGP_LPJ_G0032793	protein coding gene	Chr7:118657966-118719104 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032684	protein coding gene	Chr7:127513839-127591664 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033390	protein coding gene	Chr7:116073575-116137361 (+)
PWK/PhJ	MGP_PWKPhJ_G0031609	protein coding gene	Chr7:105122090-105180246 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031457	protein coding gene	Chr7:102840166-102896405 (+)
WSB/EiJ	MGP_WSBEiJ_G0032015	protein coding gene	Chr7:116942817-117002132 (+)

Human Ortholog

FAR1, fatty acyl-CoA reductase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAR1, fatty acyl-CoA reductase 1
Synonyms

CSPSD, MLSTD2, PFCRD, SDR10E1
Links

HGNC:26222

NCBI Gene ID: 84188

neXtProt AC: NX_Q8WVX9

UniProt: Q8WVX9
Chr Location

11p15.3; chr11:13668659-13732346 (+) GRCh38

MGI Vertebrate Homology

Far1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FAR1
Gene Tree

Far1

Diseases

1 with human FAR1 associations

				Human Disease	Mouse Models
				rhizomelic chondrodysplasia punctate type 4 IDs rhizomelic chondrodysplasia punctate type 4 DOID:0081243 OMIM:616154 ORDO:438178

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

18 phenotypes from 1 allele in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

1
Targeted

4
Genomic Mutations

1 involving Far1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele show partial preweaning lethality, postnatal growth retardation, small testes, and male infertility associated with azoospermia, spermatogenesis arrest, disrupted intercellular bridge formation, multinucleated giant germ cells, and increased male germ cell apoptosis.

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All GO Annotations

18
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

13

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase far1

ZFIN far1

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All Sequences

75
RefSeq

16
UniProt

4
CCDS

CCDS40093.1, CCDS72024.1

Ensembl

ENSMUSG00000030759 (Evidence)
NCBI Gene

67420

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030759	Ensembl Gene Model \| MGI Sequence Detail	57678	C57BL/6J	± kb
transcript	ENSMUST00000164745	Ensembl \| MGI Sequence Detail	3972	Not Applicable
polypeptide	ENSMUSP00000128695	Ensembl \| MGI Sequence Detail	515	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000007341 fatty acyl-CoA reductase 1

(term hierarchy)
EC

1.2.1.84
InterPro Domains

IPR026055 Fatty acyl-CoA reductase

IPR033640 Fatty acyl-CoA reductase, C-terminal

IPR013120 Fatty acyl-coenzyme A reductase, NAD-binding domain

IPR036291 NAD(P)-binding domain superfamily

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All nucleic 14

cDNA 14

Microarray probesets 10

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MGI:1917555, MGI:1920154, MGI:2142053

Summaries

All 42

Gene Ontology 8

Phenotypes 16
Earliest

J:61682 Hagiwara N, et al., Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4180-5
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Far1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68617	Chr7:113112024-113112027 (+)	-1,015 bp
Tssr68618	Chr7:113113022-113113034 (+)	-13 bp
Tssr68619	Chr7:113113036-113113053 (+)	4 bp
Tssr68620	Chr7:113113061-113113116 (+)	48 bp
Tssr68621	Chr7:113113292-113113316 (+)	263 bp
Tssr68622	Chr7:113113318-113113346 (+)	291 bp
Tssr68623	Chr7:113113371-113113376 (+)	333 bp
Tssr68624	Chr7:113155981-113156030 (+)	42,965 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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