Ssr3 MGI Mouse Gene Detail - MGI:1914687 - signal sequence receptor, gamma

Symbol

Ssr3
Name

signal sequence receptor, gamma
Synonyms

0610038P07Rik, translocon-associated protein gamma, Trap-gamma

Feature Type

protein coding gene
IDs

MGI:1914687
NCBI Gene: 67437
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr3:65287078-65299974 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 30.15 cM
Mapping Data

2 experiments

SNPs within 2kb

345 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914687	protein coding gene	Chr3:65287076-65300044 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027271	protein coding gene	Chr3:64492158-64505682 (-)
A/J	MGP_AJ_G0027232	protein coding gene	Chr3:62621819-62634787 (-)
AKR/J	MGP_AKRJ_G0027201	protein coding gene	Chr3:63898693-63911648 (-)
BALB/cJ	MGP_BALBcJ_G0027244	protein coding gene	Chr3:62441862-62454880 (-)
C3H/HeJ	MGP_C3HHeJ_G0026988	protein coding gene	Chr3:64192001-64204969 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027690	protein coding gene	Chr3:66924806-66937765 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025043	protein coding gene	Chr3:59020500-59034308 (-)
CAST/EiJ	MGP_CASTEiJ_G0026435	protein coding gene	Chr3:64135490-64148465 (-)
CBA/J	MGP_CBAJ_G0026963	protein coding gene	Chr3:68996812-69009815 (-)
DBA/2J	MGP_DBA2J_G0027099	protein coding gene	Chr3:62120201-62133198 (-)
FVB/NJ	MGP_FVBNJ_G0027067	protein coding gene	Chr3:60764249-60777747 (-)
LP/J	MGP_LPJ_G0027207	protein coding gene	Chr3:65409191-65423316 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027085	protein coding gene	Chr3:73602053-73615960 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027748	protein coding gene	Chr3:63807641-63820605 (-)
PWK/PhJ	MGP_PWKPhJ_G0026169	protein coding gene	Chr3:61866682-61879900 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025985	protein coding gene	Chr3:63014932-63027190 (-)
WSB/EiJ	MGP_WSBEiJ_G0026513	protein coding gene	Chr3:63939359-63952421 (-)

Human Ortholog

SSR3, signal sequence receptor subunit 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SSR3, signal sequence receptor subunit 3
Synonyms

TRAPG
Links

HGNC:11325

NCBI Gene ID: 6747

neXtProt AC: NX_Q9UNL2

UniProt: Q9UNL2
Chr Location

3q25.31; chr3:156539553-156555149 (-) GRCh38

MGI Vertebrate Homology

Ssr3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SSR3
Gene Tree

Ssr3

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References

1 with disease annotations

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

6
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Ssr3
Incidental Mutations

APF
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display neonatal lethality with growth retardation, reduced placental size and impaired placental vascular development.

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All GO Annotations

3
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

12
cDNA Data

398
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ssr3

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All Sequences

54
RefSeq

2
UniProt

3
CCDS

CCDS17386.1

Ensembl

ENSMUSG00000027828 (Evidence)
NCBI Gene

67437

			Length	Strain/Species	Flank
genomic	67437	NCBI Gene Model \| MGI Sequence Detail	12897	C57BL/6J	± kb
transcript	NM_026155	RefSeq \| MGI Sequence Detail	2885	C57BL/6
polypeptide	Q9DCF9	UniProt \| EBI \| MGI Sequence Detail	185	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015661 translocon-associated protein subunit gamma

(term hierarchy)
InterPro Domains

IPR009779 Translocon-associated protein subunit gamma
GlyGen

Q9DCF9 1 site, 1 O-linked glycan (1 site)

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All nucleic 398

cDNA 398

Microarray probesets 6

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MGI:2139852, MGI:2139887, MGI:2140004

Summaries

All 37

Developmental Gene Expression 3

Diseases 1

Gene Ontology 3

Phenotypes 10
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Ssr3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr33465	Chr3:65300000-65300016 (-)	-34 bp
Tssr33464	Chr3:65299967-65299983 (-)	-1 bp
Tssr893	Chr3:65298402-65298407 (-)	1,569 bp
Tssr33463	Chr3:65288817-65288821 (-)	11,155 bp
Tssr33462	Chr3:65288697-65288710 (-)	11,270 bp
Tssr33461	Chr3:65288461-65288478 (-)	11,504 bp
Tssr33460	Chr3:65288352-65288369 (-)	11,613 bp
Tssr33459	Chr3:65288203-65288214 (-)	11,765 bp
Tssr33458	Chr3:65287728-65287742 (-)	12,239 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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