Rfk MGI Mouse Gene Detail - MGI:1914688

Symbol

Rfk
Name

riboflavin kinase
Synonyms

0610038L10Rik, ATP:riboflavin 5'-phosphotransferase, flavokinase

Feature Type

protein coding gene
IDs

MGI:1914688
NCBI Gene: 54391
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr19:17371407-17378713 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 12.82 cM, cytoband B
Mapping Data

4 experiments

SNPs within 2kb

309 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914688	protein coding gene	Chr19:17371407-17378713 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024964	protein coding gene	Chr19:15215004-15222247 (+)
A/J	MGP_AJ_G0024941	protein coding gene	Chr19:14328237-14335466 (+)
AKR/J	MGP_AKRJ_G0024911	protein coding gene	Chr19:14900131-14908270 (+)
BALB/cJ	MGP_BALBcJ_G0024940	protein coding gene	Chr19:14373248-14381498 (+)
C3H/HeJ	MGP_C3HHeJ_G0024698	protein coding gene	Chr19:14845982-14853269 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025382	protein coding gene	Chr19:15779917-15787929 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022801	protein coding gene	Chr19:14757419-14764818 (+)
CAST/EiJ	MGP_CASTEiJ_G0024166	protein coding gene	Chr19:14465203-14472532 (+)
CBA/J	MGP_CBAJ_G0024676	protein coding gene	Chr19:16326105-16334466 (+)
DBA/2J	MGP_DBA2J_G0024808	protein coding gene	Chr19:14369116-14376450 (+)
FVB/NJ	MGP_FVBNJ_G0024769	protein coding gene	Chr19:14287977-14295199 (+)
LP/J	MGP_LPJ_G0024892	protein coding gene	Chr19:15187379-15194631 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024796	protein coding gene	Chr19:16216217-16223435 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025437	protein coding gene	Chr19:14839327-14846475 (+)
PWK/PhJ	MGP_PWKPhJ_G0023915	protein coding gene	Chr19:13909592-13916817 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023720	protein coding gene	Chr19:14131551-14139050 (+)
WSB/EiJ	MGP_WSBEiJ_G0024234	protein coding gene	Chr19:14887692-14896134 (+)

Human Ortholog

RFK, riboflavin kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RFK, riboflavin kinase
Synonyms

RIFK
Links

HGNC:30324

NCBI Gene ID: 55312

neXtProt AC: NX_Q969G6

UniProt: Q969G6
Chr Location

9q21.13; chr9:76385526-76394517 (-) GRCh38

MGI Vertebrate Homology

Rfk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RFK
Gene Tree

Rfk

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Phenotype Summary

12 phenotypes from 3 alleles in 3 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele die in utero prior to E7.5.

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All GO Annotations

26
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

115
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rfk

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All Sequences

41
RefSeq

2
UniProt

1
CCDS

CCDS29688.1

Ensembl

ENSMUSG00000024712 (Evidence)
NCBI Gene

54391

			Length	Strain/Species	Flank
genomic	54391	NCBI Gene Model \| MGI Sequence Detail	7307	C57BL/6J	± kb
transcript	NM_019437	RefSeq \| MGI Sequence Detail	2482	C57BL/6
polypeptide	Q8CFV9	UniProt \| EBI \| MGI Sequence Detail	155	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013911 riboflavin kinase

(term hierarchy)
EC

2.7.1.26
InterPro Domains

IPR023468 Riboflavin kinase

IPR015865 Riboflavin kinase domain, bacterial/eukaryotic

IPR023465 Riboflavin kinase domain superfamily

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All nucleic 116

cDNA 116

Microarray probesets 5

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MGI:2147470

Summaries

All 40

Developmental Gene Expression 1

Gene Ontology 13

Phenotypes 7
Earliest

J:335801 Merrill AH Jr, et al., Preparation of flavin 5'-phosphates using immobilized flavokinase. Methods Enzymol. 1980;66:287-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rfk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155430	Chr19:17371401-17371455 (+)	21 bp
Tssr155431	Chr19:17371460-17371486 (+)	66 bp
Tssr155432	Chr19:17372154-17372204 (+)	772 bp
Tssr155433	Chr19:17372393-17372401 (+)	990 bp
Tssr155434	Chr19:17376972-17376986 (+)	5,572 bp
Tssr155435	Chr19:17377547-17377563 (+)	6,148 bp
Tssr155436	Chr19:17377600-17377654 (+)	6,220 bp
Tssr155437	Chr19:17377906-17377910 (+)	6,501 bp
Tssr155438	Chr19:17378482-17378486 (+)	7,077 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24