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Xab2 Gene Detail
Summary
  • Symbol
    Xab2
  • Name
    XPA binding protein 2
  • Synonyms
    0610041O14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914689
    NCBI Gene: 67439
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:3660089-3671311 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 1.92 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    277 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914689
 protein coding gene Chr8:3658421-3671316 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033309
 protein coding gene Chr8:553476-566132 (-)
A/J MGP_AJ_G0033292
 protein coding gene Chr8:524003-537680 (-)
AKR/J MGP_AKRJ_G0033223
 protein coding gene Chr8:552525-565420 (-)
BALB/cJ MGP_BALBcJ_G0033292
 protein coding gene Chr8:548785-562201 (-)
C3H/HeJ MGP_C3HHeJ_G0033006
 protein coding gene Chr8:564847-578441 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033802
 protein coding gene Chr8:595667-608506 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030775
 protein coding gene Chr8:474476-487778 (-)
CAST/EiJ MGP_CASTEiJ_G0032329
 protein coding gene Chr8:558944-571607 (-)
CBA/J MGP_CBAJ_G0032979
 protein coding gene Chr8:610141-623084 (-)
DBA/2J MGP_DBA2J_G0033133
 protein coding gene Chr8:495270-508165 (-)
FVB/NJ MGP_FVBNJ_G0033080
 protein coding gene Chr8:543793-556982 (-)
LP/J MGP_LPJ_G0033225
 protein coding gene Chr8:537890-550724 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033115
 protein coding gene Chr8:589494-603134 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033820
 protein coding gene Chr8:545987-559543 (-)
PWK/PhJ MGP_PWKPhJ_G0032039
 protein coding gene Chr8:522892-535914 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031883
 protein coding gene Chr8:535980-548643 (-)
WSB/EiJ MGP_WSBEiJ_G0032442
 protein coding gene Chr8:540810-554514 (-)



Homology
more
  • Human Ortholog
    XAB2, XPA binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    XAB2, XPA binding protein 2
  • Synonyms
    HCNP, HCRN, NTC90, SYF1
  • Links
    NCBI Gene ID: 56949
    neXtProt AC: NX_Q9HCS7
    UniProt: Q9HCS7

  • Chr Location
    19p13.2; chr19:7619525-7629545 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null embryos die by the blastocyst stage (E3.5) and some eight-cell stage embryos do not undergo compaction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    11
  • cDNA Data
    91
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67439 NCBI Gene Model | MGI Sequence Detail 11223 C57BL/6J ±  kb
transcript NM_026156 RefSeq | MGI Sequence Detail 2654 ZRU/MplStud  
polypeptide Q9DCD2 UniProt | EBI | MGI Sequence Detail 855 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 92
    cDNA 92

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142733
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:328615 Goulielmaki E, et al., The splicing factor XAB2 interacts with ERCC1-XPF and XPG for R-loop processing. Nat Commun. 2021 May 26;12(1):3153
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory