Ikbip MGI Mouse Gene Detail - MGI:1914704 - IKBKB interacting protein

Symbol

Ikbip
Name

IKBKB interacting protein
Synonyms

1200009F10Rik, 1700023M03Rik

Feature Type

protein coding gene
IDs

MGI:1914704
NCBI Gene: 67454
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:90918802-90938469 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 45.54 cM, cytoband C2
Mapping Data

3 experiments

SNPs within 2kb

679 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914704	protein coding gene	Chr10:90918667-90938475 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017643	protein coding gene	Chr10:92360172-92386137 (+)
A/J	MGP_AJ_G0017622	protein coding gene	Chr10:89163437-89185578 (+)
AKR/J	MGP_AKRJ_G0017580	protein coding gene	Chr10:91714439-91742763 (+)
BALB/cJ	MGP_BALBcJ_G0017585	protein coding gene	Chr10:89448240-89467857 (+)
C3H/HeJ	MGP_C3HHeJ_G0017408	protein coding gene	Chr10:91740728-91763051 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018042	protein coding gene	Chr10:95427392-95448514 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015724	protein coding gene	Chr10:84835499-84855626 (+)
CAST/EiJ	MGP_CASTEiJ_G0016973	protein coding gene	Chr10:91666262-91689645 (+)
CBA/J	MGP_CBAJ_G0017377	protein coding gene	Chr10:99363321-99384990 (+)
DBA/2J	MGP_DBA2J_G0017483	protein coding gene	Chr10:88284691-88304078 (+)
FVB/NJ	MGP_FVBNJ_G0017475	protein coding gene	Chr10:87506606-87527715 (+)
LP/J	MGP_LPJ_G0017557	protein coding gene	Chr10:92994354-93015176 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017506	protein coding gene	Chr10:100815563-100839089 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018079	protein coding gene	Chr10:91614944-91634166 (+)
PWK/PhJ	MGP_PWKPhJ_G0016754	protein coding gene	Chr10:88339633-88364515 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016542	protein coding gene	Chr10:90375467-90396862 (+)
WSB/EiJ	MGP_WSBEiJ_G0017032	protein coding gene	Chr10:91581723-91603666 (+)

Human Ortholog

IKBIP, IKBKB interacting protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IKBIP, IKBKB interacting protein
Synonyms

IKIP
Links

HGNC:26430

NCBI Gene ID: 121457

neXtProt AC: NX_Q70UQ0

UniProt: Q70UQ0
Chr Location

12q23.1; chr12:98613404-98645113 (-) GRCh38

MGI Vertebrate Homology

Ikbip stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IKBIP
Gene Tree

Ikbip

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

3
Transposon induced

1
Genomic Mutations

2 involving Ikbip
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice with macrophage specific deletion display increased cytokine levels and mortality following LPS challenge and increased sensitivity to induced colitis.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

737
Tissues

3
cDNA Data

28
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ikbip

ZFIN ikbip

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All Sequences

50
RefSeq

10
UniProt

2
CCDS

CCDS24119.1, CCDS36031.1

Ensembl

ENSMUSG00000019975 (Evidence)
NCBI Gene

67454

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019975	Ensembl Gene Model \| MGI Sequence Detail	19668	C57BL/6J	± kb
transcript	ENSMUST00000020149	Ensembl \| MGI Sequence Detail	3232	Not Applicable
polypeptide	ENSMUSP00000020149	Ensembl \| MGI Sequence Detail	373	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008978 inhibitor of nuclear factor kappa-B kinase-interacting protein

(term hierarchy)
InterPro Domains

IPR024152 Inhibitor of nuclear factor kappa-B kinase-interacting protein
GlyGen

Q9DBZ1 1 site

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All nucleic 28

cDNA 28

Microarray probesets 4

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MGI:1916685, MGI:2143953

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 9
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:282971 Wu H, et al., IKIP Negatively Regulates NF-kappaB Activation and Inflammation through Inhibition of IKKalpha/beta Phosphorylation. J Immunol. 2020 Jan 15;204(2):418-427

TSS for Ikbip:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95222	Chr10:90917953-90917965 (+)	-843 bp
Tssr95223	Chr10:90918886-90918890 (+)	86 bp
Tssr95224	Chr10:90918898-90918937 (+)	116 bp
Tssr95225	Chr10:90918943-90918965 (+)	152 bp
Tssr95226	Chr10:90932556-90932559 (+)	13,756 bp
Tssr95227	Chr10:90932991-90933002 (+)	14,195 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24