Eepd1 MGI Mouse Gene Detail - MGI:1914734 - endonuclease/exonuclease/phosphatase family domain containing 1

Symbol

Eepd1
Name

endonuclease/exonuclease/phosphatase family domain containing 1
Synonyms

2310005P05Rik

Feature Type

protein coding gene
IDs

MGI:1914734
NCBI Gene: 67484
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr9:25392843-25515406 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 10.25 cM, cytoband A4
Mapping Data

3 experiments

SNPs within 2kb

3730 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914734	protein coding gene	Chr9:25392809-25515406 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034498	protein coding gene	Chr9:22906835-23033152 (+)
A/J	MGP_AJ_G0034476	protein coding gene	Chr9:22426377-22545999 (+)
AKR/J	MGP_AKRJ_G0034402	protein coding gene	Chr9:22843930-22972910 (+)
BALB/cJ	MGP_BALBcJ_G0034467	protein coding gene	Chr9:22308062-22432123 (+)
C3H/HeJ	MGP_C3HHeJ_G0034179	protein coding gene	Chr9:23184229-23312139 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034988	protein coding gene	Chr9:23792354-23918305 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031918	protein coding gene	Chr9:21379536-21496052 (+)
CAST/EiJ	MGP_CASTEiJ_G0033502	protein coding gene	Chr9:23073457-23202951 (+)
CBA/J	MGP_CBAJ_G0034152	protein coding gene	Chr9:24661618-24798315 (+)
DBA/2J	MGP_DBA2J_G0034310	protein coding gene	Chr9:22402630-22522240 (+)
FVB/NJ	MGP_FVBNJ_G0034253	protein coding gene	Chr9:21878944-21998568 (+)
LP/J	MGP_LPJ_G0034396	protein coding gene	Chr9:23085450-23209770 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034297	protein coding gene	Chr9:26295095-26417940 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035008	protein coding gene	Chr9:22838511-22966399 (+)
PWK/PhJ	MGP_PWKPhJ_G0033207	protein coding gene	Chr9:22346386-22466923 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033041	protein coding gene	Chr9:22886722-23014251 (+)
WSB/EiJ	MGP_WSBEiJ_G0033617	protein coding gene	Chr9:22555426-22678095 (+)

Human Ortholog

EEPD1, endonuclease/exonuclease/phosphatase family domain containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EEPD1, endonuclease/exonuclease/phosphatase family domain containing 1
Synonyms

HSPC107
Links

HGNC:22223

NCBI Gene ID: 80820

neXtProt AC: NX_Q7L9B9

UniProt: Q7L9B9
Chr Location

7p14.2; chr7:36153254-36301538 (+) GRCh38

MGI Vertebrate Homology

Eepd1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EEPD1
Gene Tree

Eepd1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Gene trapped

1
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

5
cDNA Data

36
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eepd1

ZFIN eepd1

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All Sequences

46
RefSeq

9
UniProt

1
CCDS

CCDS22935.1

Ensembl

ENSMUSG00000036611 (Evidence)
NCBI Gene

67484

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036611	Ensembl Gene Model \| MGI Sequence Detail	122564	C57BL/6J	± kb
transcript	ENSMUST00000040677	Ensembl \| MGI Sequence Detail	2723	Not Applicable
polypeptide	ENSMUSP00000047083	Ensembl \| MGI Sequence Detail	569	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000032525 endonuclease/exonuclease/phosphatase family domain-containing protein 1

(term hierarchy)
InterPro Domains

IPR004509 Competence protein ComEA, helix-hairpin-helix domain

IPR005135 Endonuclease/exonuclease/phosphatase

IPR051675 Endonuclease/exonuclease/phosphatase family domain-containing protein 1

IPR036691 Endonuclease/exonuclease/phosphatase superfamily

IPR003583 Helix-hairpin-helix DNA-binding motif, class 1

IPR010994 RuvA domain 2-like
GlyGen

Q3TGW2 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 36

cDNA 36

Microarray probesets 4

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MGI:2143081

Summaries

All 35

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Eepd1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84145	Chr9:25392847-25392858 (+)	10 bp
Tssr84146	Chr9:25392886-25392908 (+)	54 bp
Tssr84147	Chr9:25392919-25392930 (+)	82 bp
Tssr84148	Chr9:25402425-25402431 (+)	9,585 bp
Tssr84149	Chr9:25415705-25415720 (+)	22,870 bp
Tssr84150	Chr9:25415726-25415747 (+)	22,894 bp
Tssr84151	Chr9:25426564-25426568 (+)	33,723 bp
Tssr84152	Chr9:25473972-25474001 (+)	81,144 bp
Tssr84153	Chr9:25481906-25481917 (+)	89,069 bp
Tssr84154	Chr9:25481919-25481929 (+)	89,081 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24