Calcoco1 MGI Mouse Gene Detail - MGI:1914738 - calcium binding and coiled coil domain 1

Symbol

Calcoco1
Name

calcium binding and coiled coil domain 1
Synonyms

1810009B06Rik, CoCoA, Gcap11

Feature Type

protein coding gene
IDs

MGI:1914738
NCBI Gene: 67488
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:102615212-102630613 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 57.81 cM, cytoband F3
Mapping Data

3 experiments

SNPs within 2kb

402 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914738	protein coding gene	Chr15:102615212-102630616 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022423	protein coding gene	Chr15:104917022-104932485 (-)
A/J	MGP_AJ_G0022385	protein coding gene	Chr15:100780907-100796306 (-)
AKR/J	MGP_AKRJ_G0022360	protein coding gene	Chr15:103843814-103859257 (-)
BALB/cJ	MGP_BALBcJ_G0022389	protein coding gene	Chr15:100827025-100842424 (-)
C3H/HeJ	MGP_C3HHeJ_G0022156	protein coding gene	Chr15:103915893-103931271 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022838	protein coding gene	Chr15:108806188-108823556 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020361	protein coding gene	Chr15:96553431-96569231 (-)
CAST/EiJ	MGP_CASTEiJ_G0021682	protein coding gene	Chr15:104781628-104797807 (-)
CBA/J	MGP_CBAJ_G0022125	protein coding gene	Chr15:112630179-112648094 (-)
DBA/2J	MGP_DBA2J_G0022256	protein coding gene	Chr15:100054944-100070753 (-)
FVB/NJ	MGP_FVBNJ_G0022232	protein coding gene	Chr15:99118557-99134700 (-)
LP/J	MGP_LPJ_G0022325	protein coding gene	Chr15:105057292-105072692 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022254	protein coding gene	Chr15:116169767-116186338 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022850	protein coding gene	Chr15:103881214-103899747 (-)
PWK/PhJ	MGP_PWKPhJ_G0021422	protein coding gene	Chr15:100225494-100241901 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021254	protein coding gene	Chr15:103712618-103729591 (-)
WSB/EiJ	MGP_WSBEiJ_G0021732	protein coding gene	Chr15:104495575-104511913 (-)

Human Ortholog

CALCOCO1, calcium binding and coiled-coil domain 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CALCOCO1, calcium binding and coiled-coil domain 1
Synonyms

calphoglin, Cocoa, PP13275
Links

HGNC:29306

NCBI Gene ID: 57658

neXtProt AC: NX_Q9P1Z2

UniProt: Q9P1Z2
Chr Location

12q13.13; chr12:53708517-53727745 (-) GRCh38

MGI Vertebrate Homology

Calcoco1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CALCOCO1
Gene Tree

Calcoco1

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References

1 with disease annotations

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

2
Targeted

6
Genomic Mutations

2 involving Calcoco1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

34
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

717
Tissues

7
cDNA Data

82
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

58
RefSeq

4
UniProt

6
CCDS

CCDS27889.1

Ensembl

ENSMUSG00000023055 (Evidence)
NCBI Gene

67488

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023055	Ensembl Gene Model \| MGI Sequence Detail	15402	C57BL/6J	± kb
transcript	ENSMUST00000023818	Ensembl \| MGI Sequence Detail	2824	Not Applicable
polypeptide	ENSMUSP00000023818	Ensembl \| MGI Sequence Detail	691	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000004970 calcium-binding and coiled-coil domain-containing protein 1

(term hierarchy)
InterPro Domains

IPR012852 Calcium binding and coiled-coil domain-like

IPR041641 CALCOCO1/2, zinc finger UBZ1-type

IPR041611 SKICH domain

IPR051002 Ubiquitin-binding and autophagy-associated domain-containing protein
GlyGen

Q8CGU1 1 site, 1 N-linked glycan (1 site)

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All nucleic 83

cDNA 83

Microarray probesets 3

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MGD-MRK-18684, MGI:101860

Summaries

All 59

Developmental Gene Expression 3

Diseases 1

Gene Ontology 9

Phenotypes 29
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Calcoco1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136718	Chr15:102630585-102630597 (-)	22 bp
Tssr136717	Chr15:102630555-102630572 (-)	49 bp
Tssr136716	Chr15:102630496-102630549 (-)	90 bp
Tssr136715	Chr15:102615773-102615850 (-)	14,801 bp
Tssr136714	Chr15:102615506-102615519 (-)	15,100 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24