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Agpat2 Gene Detail
Summary
  • Symbol
    Agpat2
  • Name
    1-acylglycerol-3-phosphate O-acyltransferase 2
  • Synonyms
    2510002J07Rik, BSCL1, LPAAT-beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914762
    NCBI Gene: 67512
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:26483069-26494429 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 18.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    356 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914762
 protein coding gene Chr2:26483069-26494429 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025493
 protein coding gene Chr2:24554093-24567416 (-)
A/J MGP_AJ_G0025470
 protein coding gene Chr2:23612439-23624863 (-)
AKR/J MGP_AKRJ_G0025440
 protein coding gene Chr2:24375247-24390955 (-)
BALB/cJ MGP_BALBcJ_G0025466
 protein coding gene Chr2:23722951-23734799 (-)
C3H/HeJ MGP_C3HHeJ_G0025227
 protein coding gene Chr2:24338869-24350189 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025910
 protein coding gene Chr2:25353499-25364757 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023321
 protein coding gene Chr2:22490762-22502000 (-)
CAST/EiJ MGP_CASTEiJ_G0024690
 protein coding gene Chr2:24215597-24227068 (-)
CBA/J MGP_CBAJ_G0025205
 protein coding gene Chr2:26197775-26213341 (-)
DBA/2J MGP_DBA2J_G0025338
 protein coding gene Chr2:23432959-23444624 (-)
FVB/NJ MGP_FVBNJ_G0025300
 protein coding gene Chr2:23190244-23202389 (-)
LP/J MGP_LPJ_G0025424
 protein coding gene Chr2:24497909-24509197 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025331
 protein coding gene Chr2:26340503-26351812 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025969
 protein coding gene Chr2:24333031-24345804 (-)
PWK/PhJ MGP_PWKPhJ_G0024438
 protein coding gene Chr2:23241069-23254662 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024238
 protein coding gene Chr2:24475794-24485904 (-)
WSB/EiJ MGP_WSBEiJ_G0024759
 protein coding gene Chr2:24441894-24454455 (-)



Homology
more
  • Human Ortholog
    AGPAT2, 1-acylglycerol-3-phosphate O-acyltransferase 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGPAT2, 1-acylglycerol-3-phosphate O-acyltransferase 2
  • Synonyms
    1-AGPAT2, BSCL, BSCL1, LPAAB, LPAAT-beta, LPLAT2
  • Links
    NCBI Gene ID: 10555
    neXtProt AC: NX_O15120
    UniProt: O15120

  • Chr Location
    9q34.3; chr9:136673143-136687457 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Agpat2 mouse models; 2 with human AGPAT2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    78 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit loss of white and brown adipose tissue, insulin resistance, and hepatic steatosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    824
  • Tissues
    95
  • cDNA Data
    83
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67512 NCBI Gene Model | MGI Sequence Detail 11361 C57BL/6J ±  kb
    transcript NM_026212 RefSeq | MGI Sequence Detail 1574 C57BL/6  
    polypeptide Q8K3K7 UniProt | EBI | MGI Sequence Detail 278 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 85
      cDNA 84
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139227
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:351217 Agarwal AK, et al., Adipose-specific overexpression of human AGPAT2 in mice causes increased adiposity and mild hepatic dysfunction. iScience. 2024 Jan 19;27(1):108653
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory