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Nudt7 Gene Detail
Summary
  • Symbol
    Nudt7
  • Name
    nudix hydrolase 7
  • Synonyms
    1300007B24Rik, 2210404C19Rik, nudix (nucleoside diphosphate linked moiety X)-type motif 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914778
    NCBI Gene: 67528
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:114860314-114881471 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 60.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    868 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914778
 protein coding gene Chr8:114860297-114881479 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034158
 protein coding gene Chr8:117095164-117117401 (+)
A/J MGP_AJ_G0034138
 protein coding gene Chr8:112297583-112319222 (+)
AKR/J MGP_AKRJ_G0034065
 protein coding gene Chr8:115610456-115631942 (+)
BALB/cJ MGP_BALBcJ_G0034132
 protein coding gene Chr8:112514348-112536159 (+)
C3H/HeJ MGP_C3HHeJ_G0033843
 protein coding gene Chr8:116290373-116312347 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034652
 protein coding gene Chr8:121105947-121126911 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031594
 protein coding gene Chr8:105330745-105349511 (+)
CAST/EiJ MGP_CASTEiJ_G0033170
 protein coding gene Chr8:116023282-116044974 (+)
CBA/J MGP_CBAJ_G0033816
 protein coding gene Chr8:125362879-125383537 (+)
DBA/2J MGP_DBA2J_G0033972
 protein coding gene Chr8:111558789-111579407 (+)
FVB/NJ MGP_FVBNJ_G0033915
 protein coding gene Chr8:110546151-110569346 (+)
LP/J MGP_LPJ_G0034061
 protein coding gene Chr8:117242391-117263328 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033962
 protein coding gene Chr8:128135879-128157343 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034670
 protein coding gene Chr8:115647302-115669705 (+)
PWK/PhJ MGP_PWKPhJ_G0032872
 protein coding gene Chr8:111256723-111278235 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032712
 protein coding gene Chr8:114294100-114316290 (+)
WSB/EiJ MGP_WSBEiJ_G0033286
 protein coding gene Chr8:116338161-116359960 (+)



Homology
more
  • Human Ortholog
    NUDT7, nudix hydrolase 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUDT7, nudix hydrolase 7
  • Links
    NCBI Gene ID: 283927
    neXtProt AC: NX_P0C024
    UniProt: P0C024

  • Chr Location
    16q23.1; chr16:77722492-77742260 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased susceptibility to DMM surgery-induced osteoarthritis or severe cartilage degeneration on a phytol enriched diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    55
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67528 NCBI Gene Model | MGI Sequence Detail 21158 C57BL/6J ±  kb
    transcript NM_001290181 RefSeq | MGI Sequence Detail 2839 C57BL/6  
    polypeptide Q99P30 UniProt | EBI | MGI Sequence Detail 236 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 58

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1919529
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 6
    • Earliest
      J:68231 Cartwright JL, et al., The Saccharomyces cerevisiae PCD1 gene encodes a peroxisomal nudix hydrolase active toward coenzyme A and its derivatives. J Biol Chem. 2000 Oct 20;275(42):32925-30
    • Latest
      J:342276 Song J, et al., Upregulated FOXM1 stimulates chondrocyte senescence in Acot12(-/-)Nudt7(-/-) double knockout mice. Theranostics. 2023;13(15):5207-5222
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory